Search for dissertations about: "CYP2D6"

Showing result 1 - 5 of 41 swedish dissertations containing the word CYP2D6.

  1. 1. Pharmacogenetic analysis in sickness and in health - for better or for worse

    Author : Mia Wadelius; Uppsala universitet; []
    Keywords : Medical sciences; Pharmacogenetics; NAT2; CYP2D6; CYP2C19; CYP17; GSTP1; sulphasalazine; agranulocytosis; prostate cancer; pregnancy; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; klinisk farmakologi; Clinical Pharmacology;

    Abstract : An individual's pharmacogenetic constitution may predict response to drugs, hormones and toxins, and might be a susceptibility factor for disease. Pharmacogenetic diversity is especially pronounced for drug metabolising enzymes. READ MORE

  2. 2. Migraine in women : Epidemiological, clinical, genetic, and experimental aspects

    Author : Peter Mattsson; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Migraine; aura; prevalence; age; CYP2D6; GSTM1; cold induced headache; Neurovetenskap; Neurology; Neurologi; Neurology; neurologi;

    Abstract : Migraine is a significant public-health problem. Few studies have focused on migraine inmiddle-aged and older women in the general population. READ MORE

  3. 3. First-pass Intestinal Metabolism of Drugs : Experiences from in vitro, in vivo and simulation studies

    Author : Helena Anna Thörn; Hans Lennernäs; Paul Alfred Dickinson; Brian Houston; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacokinetics; metabolism; CYP3A4; CYP2C9; CYP2D6; UGT; glucuronidation; physiologically based pharmacokinetic model; modelling; Biopharmaceutics; Biofarmaci;

    Abstract : The bioavailability of a drug can be described as the fraction of an orally administered dose that reaches the systemic circulation and is often limited by first-pass metabolism in the gut and the liver. It is important to have knowledge about these processes since the systemic blood drug concentration is tightly connected to the effect of the drug. READ MORE

  4. 4. Pharmacogenetics from a Forensic Perspective : CYP2D6 and CYP2C19 genotype distributions in autopsy cases

    Author : Anna-Lena Zackrisson; Johan Ahlner; Bertil Lindblom; Magnus Ingelman-Sundberg; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : In Sweden about 550 individuals die every year due to drug intoxication. A challenge for the forensic toxicologist is to determine whether or not the analytical results can explain intoxication as a cause of death. The most common drugs found among intoxication cases are psychiatric drugs and analgesics. READ MORE

  5. 5. Pharmacokinetic consequences of CYP2D6 genotypes with emphasis on gene duplication/amplification

    Author : Per Dalén; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Drug metabolism; CYP2D6. debrisoquine; nortriptyline; quinidine; genotype; phenotype; cytochrome P450; gene duplication; gene amplification;

    Abstract : The relationship between the major Caucasian and Oriental CYP2D6 genotypes and the disposition of two CYP2D6 substrates nortriptyline and debrisoquine was investigated. Caucasians with 0, 1, 2, 3/4 and 13 functional CYP2D6-genes as well as Chinese and Korean subjects homo- and heterozygous for the CYP2D6*1 and CYP2D6*10 alleles were included. READ MORE