Search for dissertations about: "CYP2D6"

Showing result 21 - 25 of 45 swedish dissertations containing the word CYP2D6.

  2. 21. Genetic influence on enantiomeric drug disposition : Focus on venlafaxine and citalopram

    Author : Maria Kingbäck; Fredrik Kugelberg; Björn Carlsson; Martin Josefsson; Finn Bengtsson; Johan Ahlner; Anders Rane; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : A molecule that is not identical to its mirror image is said to be chiral. A racemic mixture, or a racemate, is one that has equal amounts of S- and R-enantiomers of a chiral molecule. Two examples of frequently prescribed racemic drugs are the antidepressants venlafaxine (VEN) and citalopram (CIT). READ MORE

  4. 22. Genetic polymorphism of human drug metabolising enzymes : structural and functional studies

    Author : Mikael Oscarson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : There is a pronounced interindividual variability in the levels and activity of many drug metabolising enzymes, which might cause differences in the sensitivity to and the toxicity of many clinically used drugs as well as environmental compounds such as nicotine and precarcinogens. In the present investigation the molecular genetic basis for some of the differences in the CYP2A6, CYP2D6, CYP2E1 and GSTM1 enzymes have been elucidated. READ MORE

  5. 23. Pharmacogenetics and Antipsychotic Treatment in Schizophrenia with Special Focus on Adverse Drug Reactions

    Author : Arzu Gunes; Marja-Liisa Dahl; Maria Gabriella Scordo; Kristina I. Melkersson; Jürgen Brockmöller; Uppsala universitet; []
    Keywords : Medicine; Pharmacogenetics; schizophrenia; antipsychotic treatment; adverse effects; clinical outcome; Medicin;

    Abstract : Genetically determined differences in drug metabolism and disposition and drug targets play a pivotal role in the interindividual variability in the clinical outcome of antipsychotic treatment. The aim of this thesis was to study the impact of polymorphisms in genes involved in the pharmacokinetics and pharmacodynamics of antipsychotics, with special focus on their extrapyramidal and metabolic adverse effects. READ MORE

  6. 24. Interindividual differences in xenobiotic-metabolising enzymes : the human genetic factor

    Author : Roman A McLellan; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The vast number of human xenobiotic-metabolising enzymes display interindividual variability that can alter the disposition of any compound metabolised by these enzymes, including environmental chemicals and many clinically used drugs. Both genetic and non-genetic factors affect the levels and activities of these enzymes. READ MORE

  7. 25. Studies on Variability in Olanzapine Disposition

    Author : Elisabeth Skogh; Staffan Hägg; Marja Liisa Dahl; Markus Heilig; Lena Flyckt; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : Schizophrenia and schizoaffective disorders are chronic conditions with a significant impact on many functions. Positive, negative, cognitive and motor symptoms appear in different degrees and constellations. Antipsychotics are of fundamental importance to reduce symptoms. READ MORE