Search for dissertations about: "CYP2E1"

Showing result 1 - 5 of 16 swedish dissertations containing the word CYP2E1.

  2. 1. Qualitative and Quantitative Assessment of Cytochromes P450 mRNA in Human : Studies in the Liver, Blood and Gastrointestinal Mucosa

    Author : Mari Thörn; Lars Lööf; Anders Rane; Ellen Vinge; Uppsala universitet; []
    Keywords : Medical sciences; cytochrome P450; CYP1A2; CYP1B1; CYP2E1; CYP3A4; CYP3A5; P-gp; gene expression; RT-PCR; liver; blood; gastrointestinal mucosa; MEDICIN OCH VÅRD; MEDICINE; MEDICIN;

    Abstract : Drugs and other foreign compounds must often be metabolised before they can be excreted from the body. One enzyme system that is responsible for this is the cytochrome P450 gene family (CYP). READ MORE

  4. 2. Regulation and polymorphism of CYP2A6, CYP2B6 and CYP2E1 : functional and clinical aspects

    Author : Jue Wang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Cytochrome P450; CYP2A6; CYP2B6; CYP2El; gene regulation; polymorphism; SNP; genotyping; IL4; signaling pathway;

    Abstract : Cytochrome P450s constitute a superfamily of heme-binding monooxygenases that play important roles in the metabolism of endogenous substrates and a wide variety of exogenous substances, such as toxins and drugs, and participate as well in the biosynthesis of steroids, fatty acids, vitamins and bile acids. The P450s genes are subjects for large inter-individual variability in expression, which subsequently cause inter-individual differences in drug metabolism. READ MORE

  5. 3. Drug and alcohol induced hepatotoxicity

    Author : Angelica Butura; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Hepatotoxicity; in vitro models; alcoholic liver disease; CYP2E1;

    Abstract : Drug induced hepatotoxicity is the most common reason cited for withdrawal of already approved drugs from the market and accounts for more than 50 percent of cases of acute liver failure in the United States. Ethanol (EtOH) causes a further substantial amount of liver insufficiencies world wide. READ MORE

  6. 4. Variation and comparison of cytochromes P450 in human liver and blood : with special emphasis on gene expression

    Author : Niklas Finnström; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Cytochrome P450; CY1A2; CYP1B1; CYP2E1; CYP3A4; gene expression; RTPCR; liver; blood; human; variation.;

    Abstract : The liver is the major drug and xenobiotic metabolising organ, and is the target of many adverse reactions. The main hepatic metabolic enzymes belong to the mono oxygenase enzyme family of cytochromes P450 (CYP). Direct studies of these enzymes in small liver biopsy samples require ultrasensitive methodology. READ MORE

  7. 5. Regulation of cytochrome P450 2E1 by hyperoxia and inflammatory factors, with special reference to the central nervous system

    Author : Niclas Tindberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cytochrome P450 2E1 (CYP2E1) is a mammalian member of the large P450 gene superfamily. CYP2E1 is active in the metabolism of many small hydrophobic substrates, including general anesthetics, muscle relaxants, precarcinogens, and organic solvents. READ MORE