Search for dissertations about: "CYPs"
Showing result 16 - 20 of 20 swedish dissertations containing the word CYPs.
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16. CYP2C19 and CYP2C9 : new aspects of pharmacogenetics and transcriptional regulation
Abstract : Cytochrome P450s (CYPs) are responsible for approximately 75% of the phase I-dependent drug metabolism. Several important polymorphisms in these enzymes are known to significantly affect the individual drug response. READ MORE
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17. CYP3A and lipids in health and disease : in females and males
Abstract : Sex and gender differences in the pharmacokinetics-and dynamics of drugs, have been known for centuries. Women have been regarded as different - a 70 kg male has been the norm in medicine. READ MORE
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18. CYP2C-dependent drug metabolism in vivo : influence of genetics and drug interactions
Abstract : Cytochrome P450 enzymes (CYPs) are responsible for the metabolism of the majority of therapeutic drugs. This thesis focuses on one of the CYP subfamilies, CYP2C, especially CYP2C9 and CYP2C19, which are responsible for the metabolism of 15– 20% of all drugs. All CYP2C enzymes are polymorphic, i.e. READ MORE
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19. Toxicity of smokeless tobacco in human oral epithelium with emphasis on carcinogen metabolism and regulation of programmed cell death
Abstract : The oral mucosa is globally a common site for cancer development. Primary risk factors include tobacco smoking and alcohol consumption whereas the contribution from usage of smokeless tobacco remains debated. READ MORE
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20. Studies of drug disposition in hemodialysis patients : impact of genetics, inflammation and vitamin D
Abstract : Chronic kidney disease (CKD) patients are at a high risk for drug adverse effects due to accumulation of drugs, which normally are excreted via the kidneys. It is believed that drugs that are metabolized by the liver are safe to prescribe in normal doses to end-stage renal disease (ESRD) patients. READ MORE
