Search for dissertations about: "Ca2 -channel"

Showing result 6 - 10 of 450 swedish dissertations containing the words Ca2 -channel.

  2. 6. Roles of the transient receptor potential channels and the intracellular Ca2+ channels in Ca2+ signaling in the beta-cells

    Author : Amanda Jabin Fågelskiöld; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Ca2 signaling;

    Abstract : Previous studies from our group reported that pancreatic β-cells express ryanodine receptors (RyRs) that can mediate Ca2+-induced Ca2+ release (CICR). The full consequences of the activation of RyRs on Ca2+ signaling in these cells, however, remained unclear. READ MORE

  4. 7. Regulation of Phospholipase C and Plasma Membrane Phosphatidylinositol 4,5-bisphosphate in Insulin-Secreting Cells

    Author : Sophia Thore; Anders Tengholm; Erik Gylfe; Peter Jones; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell biology; PLC; PIP2; insulin-secreting cell; Ca2 ; evanescent wave microscopy; phosphoinositide kinase; ATP ADP ratio; Cellbiologi; Cell biology; Cellbiologi;

    Abstract : The membrane phospholipid phosphatidylinositol 4,5-bisphosphate (PIP2) is an important signaling molecule as substrate for the phospholipase C (PLC)-catalyzed formation of inositol 1,4,5-trisphosphate (IP3) and diacylglycerol, and by directly regulating e.g. ion-channels, the cytoskeleton and vesicle trafficking in various types of cells. READ MORE

  5. 8. ATP Dynamics in Pancreatic α- and β-cells

    Author : Jia Li; Anders Tengholm; Erik Gylfe; Hindrik Mulder; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; ATP; Ca2 ; β-cell; α-cell; SERCA; SOCE; muscarinic receptor; insulin secretion; glucagon secretion; Medical Cell Biology; Medicinsk cellbiologi;

    Abstract : Glucose metabolism in pancreatic α- and β-cells is believed to regulate secretion of glucagon and insulin, respectively. In β-cells, ATP links glucose metabolism to electrical activity and insulin secretion. READ MORE

  6. 9. Oscillatory Signaling and Insulin Secretion from Single ß-cells

    Author : Olof Idevall Hagren; Anders Tengholm; Erik Gylfe; Leslie Satin; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cAMP; Ca2 ; oscillations; beta-cell; insulin secretion; evanescent wave microscopy; PIP3; PKA; Epac; Medical cell biology; Medicinsk cellbiologi; Medical Cell Biology; Medicinsk cellbiologi;

    Abstract : cAMP and Ca2+ are key regulators of exocytosis in many cells, including insulin-secreting pancreatic β-cells. Glucose-stimulated insulin secretion from β-cells is pulsatile and driven by oscillations of the cytoplasmic Ca2+ concentration ([Ca2+]i), but little is known about the kinetics of cAMP signaling and the mechanisms of cAMP action. READ MORE

  7. 10. Plant type II NAD(P)H dehydrogenases : Structure, regulation and evolution of NDB proteins

    Author : Mengshu Hao; Molekylär cellbiologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Arabidopsis; Ca2 ; Electron transport; NDH-2; NDB; pH; NADH; NADPH; Plant mitochondria; Potato; Type II NAD P H dehydrogenase;

    Abstract : In living organisms, respiration is a biological process degrading different carbon substrates, consuming O2, and releasing the carbon as CO2. Plants have several alternative enzymes that are involved in the respiratory processes, as compared to animals. READ MORE