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Showing result 1 - 5 of 18 swedish dissertations matching the above criteria.
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1. Oscillatory Ca2+ signaling in glucose-stimulated murine pancreatic β-cells : Modulation by amino acids, glucagon, caffeine and ryanodine
Abstract : Oscillations in cytoplasmic Ca2+ concentration ([Ca2+]i) is the key signal in glucose-stimulated β-cells governing pulsatile insulin release. The glucose response of mouse β-cells is often manifested as slow oscillations and rapid transients of [Ca2+] i. READ MORE
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2. The interplay of ions in the stimulation of the pancreatic -cell
Abstract : Glucose stimulation of insulin release is mediated by depolarisation of the pancreatic β-cells with accompanying entry of Ca2+ through voltage-dependent channels. An important feature of the glucose-induced depolarisation is its rhythmicity causing oscillations of the cytoplasmic Ca2+ concentration ([Ca2+]i), which trigger pulsatile release of insulin. READ MORE
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3. Temporal monitoring of intracellular Ca2+ signaling and origins of Ca2+ oscillations
Abstract : This thesis examined parameters influencing stimulated cytoplasmic free Ca2+ concentration ([Ca2+]i) oscillations in hepatocytes and pancreatic beta-cells. Hepatic glucose output is regulated in part by hormones such as vasopressin that act through [Ca 2+]i oscillations. READ MORE
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4. Ca2+ fluxes and insulin action in cardiac and skeletal muscles
Abstract : Obesity and type 2 diabetes are major and rapidly increasing health problems in society. They are associated with several life-threatening conditions, including heart and renal failure, and damage to the nervous system. An inability of cells to respond normally to insulin, insulin resistance, is a key feature in obesity and type 2 diabetes. READ MORE
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5. Mitochondria, contractility and Ca2+ handling : cardiac and skeletal muscle adaptations in health and disease
Abstract : Contractility is a fundamental feature of skeletal and cardiac muscles. An indispensable step in the cellular signal for contraction is a transient elevation in cytoplasmic free [Ca2+] ([Ca2+]i). Both the production of contractile force and Ca2+ handling processes are highly energy demanding. READ MORE