Search for dissertations about: "Caco-2 cells"

Showing result 6 - 10 of 51 swedish dissertations containing the words Caco-2 cells.

2. 6. Intestinal Permeability and Presystemic Extraction of Fexofenadine and R/S-verapamil

   Author : Christer Tannergren; Hans Lennernäs; Dirk KF Meijer; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biopharmacy; Bioavailability; Fexofenadine; Verapamil; P-glycoprotein; CYP3A4; OATP; Enantioselective; Permeability; Caco-2; Intestinal perfusion; Biofarmaci; Biopharmacy; Biofarmaci;

   Abstract : The main objective of this thesis was to investigate the in vivo relevance of membrane transporters and cytochrome P450 (CYP) 3A4-mediated metabolism in the intestine and liver for the bioavailability of drugs in humans after oral administration.In the first part of the thesis, the main transport mechanisms involved in the intestinal absorption and bioavailability were investigated for fexofenadine, a minimally metabolized drug, which is a substrate for P-glycoprotein (P-gp) and members of organic anion transporting polypeptide (OATP) family. READ MORE

4. 7. Magnetomotive ultrasound for nanomedicine : a mechanistic approach to detection, evaluation and safety assessment

   Author : Sandra Sjöstrand; Avdelningen för Biomedicinsk teknik; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Magnetomotive; ultrasound; finite element analysis; cancer diagnosis; HT-29; Caco-2;

   Abstract : Cancer is one of the leading causes of death worldwide, but reliable diagnosis and staging can contribute to optimal treatment planning, and is a crucial factor in reducing mortality and maintaining quality of life. Soft tissue mechanical properties are promising indicators of cancer that can be assessed non-invasively using functional imaging. READ MORE

5. 8. Factors Influencing Iron Dialyzability and Uptake in In Vitro Models

   Author : Susan Salovaara; Chalmers tekniska högskola; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; ferric iron; iron dialyzability; Caco-2 cells; pea protein; organic acids; gastrointestinal model; transit time; iron absorption; ferrous iron;

   Abstract : The availability or iron from a meal is influenced by numerous factors. This thesis deals with three of them: organic acids, plant proteins (pea and soy), and transit time through the stomach and small intestine. READ MORE

6. 9. Provitamin A Carotenoids in Orange-Fleshed Sweet Potato

   Author : Anton Bengtsson; Chalmers tekniska högskola; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; orange-fleshed sweet potato; food processing; high-performance liquid chromatography; β-carotene; β-carotene uptake; Caco-2 cells; provitamin A carotenoids; vitamin A deficiency; iron;

   Abstract : Vitamin A deficiency is a major nutritional disorder in a large number of developing countries. The disorder is mainly caused by an inadequate intake of preformed vitamin A and provitamin A carotenoids from the diet. It is also recognized that vitamin A deficiency and iron deficiency tend to coexist in many population groups. READ MORE

7. 10. Gliadin-Blocking Peptides In vitro assessment of their potential to alleviate celiac disease development

   Author : Karolina Hoffmann; Chalmers tekniska högskola; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; high-gliadin affinity blocking peptides; Caco-2 cells; in vitro digestion; tissue transglutaminase; celiac disease; gliadin; α-amylase trypsin inhibitors;

   Abstract : This thesis work aimed to investigate the potential of synthetic peptides as agents to block wheat prolamins (gliadins) that trigger the development of symptoms in celiac disease. The first step of this investigation included selection and synthesis of peptides with high affinity to gliadins and assessment of the potential of these so-called blocking peptides to limit gliadin reactivity in vitro. READ MORE