Search for dissertations about: "Calcitonin"

Showing result 11 - 15 of 77 swedish dissertations containing the word Calcitonin.

  2. 11. Role of calcitonin gene-related peptide in nociception : interactions with substance P and opioids

    Author : Long-Chuan Yu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Calcitonin gene-related peptide CGRP ; CGRP8-37; CGRP-like immunoreactivity; carrageenan; dorsal horn; dorsal root ganglion DRG ; experimentally-induced inflammtion ß-funaltrexamine ß-FNA ; hindpaw withdrawl latency HWL ; hot-plate test; ;

    Abstract : This thesis presents a study of calcitonin gene-related peptide (CGRP) and its antagonist CGRP8-37 and the interactions with substance P and opioids on the transmission of presumed nociceptive information at the spinal cord level in the rat. Significant bilateral increases in hindpaw withdrawal latency (HWL) to heat and mechanical stimulation were induced dose-dependently by intrathecal administration of 5 or 10 but no 1 nmol of CGRP8-37. READ MORE

  4. 12. Pathophysiological mechanisms involved in flap ischemia and its treatment : an experimental study with emphasis on the effects of calcitonin gene-related peptide and spinal cord stimulation on ischemia and manipulation of microcirculation in flaps

    Author : Giulio Gherardini; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ischemia; microcirculation; Calcitonin gene-related peptide; spinal cord stimulation;

    Abstract : Flap surgery and microsurgery have expanded the therapeutic options of reconstructive surgery. Partial or total flap necrosis, due to circulatory and metabolic events, is, however, still a significant problem for the plastic surgeon. READ MORE

  5. 13. The laryngeal mucosa and the superior laryngeal nerve of the rat : an immunohistochemical and electron microscopic study

    Author : Siw Domeij; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Superior laryngeal nerve; paraganglia; substance P; calcitonin gene-related peptide; neuropeptide Y; vasoactive intestinal polypeptide; enkephalin; mast cells; electron microscopy; immunohistochemistry;

    Abstract : Neuropeptides are present in nerve fibers of the upper and lower airways. Local release of these substances may be of importance for the pathophysiology of airway disorders and may play a role in responses to different stimuli. However, little is known about the distribution of neuropeptides in the larynx. READ MORE

  6. 14. Anabolic Androgenic Steroids : Effects on Neuropeptide Systems in the Rat Brain

    Author : Mathias Hallberg; Fred Nyberg; Pierre Le Grevès; James Zadina; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biological research on drug dependence; Anabolic androgenic steroids; Nandrolone decanoate; Substance P; NK1 receptor; Substance P 1-7 ; Endopeptidase; Opioids; Calcitonin gene-related peptide; Radioimmunoassay; Autoradiography; Central nervous system; Rats; Biologisk beroendeforskning; Biological research on drug dependence; Biologisk beroendeforskning;

    Abstract : Anabolic-androgenic steroids (AAS) have been used in clinics for decades. The misuse of AAS has previously been attributed merely to sport athletes, taking AAS with intentions to increase muscle mass, enhance physical performance and to improve results in competitions. READ MORE

  7. 15. Endogenous activators of the pain receptor TRPV1 From cell to man

    Author : Pouya Movahed Rad; Avdelningen för klinisk kemi och farmakologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicin människa och djur ; Medicine human and vertebrates ; cannabinoids; capsazepine; N-acylethanolamines; anandamide; blood Circulation; vasodilation; humans; calcitonin Gene-related Peptide; capsaicin; neurogenic inflammation; nociceptors; TRPV1 protein; pain;

    Abstract : N-acylethanolamines (NAEs) belong to a growing family of endogenous signalling molecules acting on a variety of receptors and ion channels. In 1992, it was reported that the N-acylethanolamine anandamide is present in the brain and activates the central cannabinoid (CB) receptor. READ MORE