Search for dissertations about: "Calcium Signaling"

Showing result 1 - 5 of 142 swedish dissertations containing the words Calcium Signaling.

  2. 1. Calcium and Phospholipases in Orexin Receptor Signaling

    Author : Lisa Johansson; Jyrki Kukkonen; Karl Åkerman; Christopher S. Leonard; Uppsala universitet; []
    Keywords : Physiology; orexin; receptor; calcium; phospholipase; cell signaling; GPCR; Fysiologi;

    Abstract : The neuropeptides orexin-A and -B act as endogenous ligands for G-protein-coupled receptors (GPCRs) called OX1 and OX2 receptors. Previous observations have established that orexin receptors have an ability to couple to different G-proteins and signaling pathways and induce Ca2+ elevations via both receptor-operated Ca2+ channels (ROCs) and store-operated Ca2+ channels (SOCs). READ MORE

  4. 2. Signaling via Orexin Receptors : A Pharmacological Study

    Author : Tomas Holmqvist; Jyrki Kukkonen; Karl Åkerman; Gunnar Flemström; Per Svenningsson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Physiology; orexin; receptors; calcium; cAMP; adenylyl cyclases; Fysiologi; Physiology; Fysiologi;

    Abstract : The orexin receptors are a pair of newly discovered G-protein coupled receptors which are activated by the neuropeptides orexins and play a role in sleep/vigilance, apetite/metabolism and neuroendocrine regulation. On a cellular level receptor activation results in, to name but a few effects, elevation of intracellular calcium and depolarisation. READ MORE

  5. 3. Calcium signaling in development and disease

    Author : Marie Karlsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The calcium ion (Ca2+) is a highly versatile signaling messenger involved in a diverse range of physiological processes such as gene transcription/expression, proliferation, differentiation and cell death. Intracellular Ca2+ signals are generated through a 10 000 – 20 000 fold gradient across the cell membrane and via release from the external milieu and/or internal Ca2+ stores. READ MORE

  6. 4. Vascular smooth muscle mechanotransduction and plasticity-the role of microRNA, calcium signaling and actin polymerization

    Author : Karolina Turczynska; Kärlfysiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PYK2; actin polymerization; calcium; microRNA; stretch;

    Abstract : Smooth muscle cells residing in the blood vessel media are constantly exposed to mechanical forces exerted by the intraluminal pressure. The smooth muscle senses and adapts to mechanical forces by activation of multiple signaling pathways and cytoskeletal rearrangements. READ MORE

  7. 5. Metal homeostasis as critical determinant for cellular fitness

    Author : Jutta Diessl; Sabrina Büttner; Rajini Rao; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; metal homeostasis; manganese toxicity; coenzyme Q synthesis; mitochondrial respiration; calcineurin signaling; Pmr1; SPCA1; calcium; survival; caloric restriction; Parkinson’s disease models; proteotoxicity; Pep4; cathepsin D; molekylär biovetenskap; Molecular Bioscience;

    Abstract : Metals play a crucial role in cellular biology. Bulk and trace metals such as calcium and manganese regulate a plethora of cellular processes ranging from signaling and oxidative stress to proteostasis and energy metabolism. READ MORE