Search for dissertations about: "Cancer Immunotherapy Clinical Trials:"

Showing result 1 - 5 of 15 swedish dissertations containing the words Cancer Immunotherapy Clinical Trials:.

  2. 1. Translational studies of metastatic melanoma in the era of immunotherapy - from humanized mouse models to clinical trials

    Author : Henrik Jespersen; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Metastatic melanoma; Uveal melanoma; Humanized mouse models; Immunotherapy; Chimeric antigen receptor T cells; PD-1 inhibition; Epigenetics; Histone deacetylase inhibition;

    Abstract : Immunotherapy with PD-1 inhibitors has transformed the treatment of met-astatic cutaneous mela- noma, and can lead to complete and durable responses in a proportion of patients. However, in around half of the patients, the treatment has little or no effect. READ MORE

  4. 2. Improved cancer survival with use of common antihistamines. Epidemiological studies on the use of H1-antihistamines and survival in cancer

    Author : Ildikó Fritz; LUCC: Lunds universitets cancercentrum; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; epidemiology; histamine H1 antagonists; histamine antagonists; chemotherapy; immunotherapy;

    Abstract : Cancer often results from chronic inflammation, and anti-inflammatory medications are therefore potential candidates for drug repurposing for cancer therapy. H2-antihistamines such as cimetidine have long been studied for their promise as cancer medications, but H1-antihistamines have thus far not been studied widely for this purpose. READ MORE

  5. 3. Neoadjuvant chemotherapy in muscle-invasive urinary bladder cancer : studies on treatment response, tumor draining lymph nodes and blood transfusion

    Author : Robert Rosenblatt; Amir Sherif; Ola Winqvist; Per Marits; Ralph Peeker; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; bladder cancer; neoadjuvant chemotherapy; tumor downstaging; sentinel nodes; blood transfusion; Urology; kirurgi; särskilt urologi; Medicine; medicin;

    Abstract : Muscle-invasive urinary bladder cancer is a deadly disease. Mortality rates remained unchanged for decades despite radical surgery.After several randomized trials, we today know that cisplatin based chemotherapy given prior to cystectomy, improves survival for every tenth patient. READ MORE

  6. 4. Delivery of DNA vaccines against cancer

    Author : Anna-Karin Roos; Karolinska Institutet; Karolinska Institutet; []
    Keywords : DNA vaccine; prostate-specific antigen; immunotherapy; prostate cancer; electroporation;

    Abstract : DNA vaccines against cancer have shown promising results in animal models. Efficient antigenspecific T cell responses and tumor protection have been demonstrated after vaccination with DNA encoding tumor antigens in mice. READ MORE

  7. 5. Dendritic cells in immune and gene therapy against cancer

    Author : Andreas Lundqvist; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Dendritic cells; immunotherapy; gene therapy;

    Abstract : Dendritic cells (DC) are extensively used for vaccine therapy due to their superior T cell stimulatory capacity. However, the modest therapeutic effects reported by most clinical trials using DC, together with the rapid developing field of DC biology suggests important considerations for improvement of the clinical outcome. READ MORE