Search for dissertations about: "Carbamates"

Showing result 1 - 5 of 14 swedish dissertations containing the word Carbamates.

  2. 1. Developmental neurotoxicity of persistent and non-persistent pollutants : Behavioral and neurochemical assessments of a perfluorinated compound, pesticides and interaction effects

    Author : Iwa Lee; Henrik Viberg; Per Eriksson; William Mundy; Uppsala universitet; []
    Keywords : Brain; Neonatal; Mixtures; Cholinergic system; Organochlorines; Pyrethroids; Organophosphates; Carbamates; Insecticides; PFCs; PFAAs; PFHxS; Endosulfan; Cypermethrin; Chlorpyrifos; Carbaryl; Biology with specialization in Environmental Toxicology; Biologi med inriktning mot miljötoxikologi;

    Abstract : The focus of this thesis was to investigate developmental neurotoxic effects of different persistent and non-persistent environmental pollutants, alone or in binary mixtures, when exposure occurs during a critical period of brain development, in mice. The compounds investigated included a perfluorinated compound, perfluorohexane sulphonate (PFHxS), and four different pesticides, endosulfan, cypermethrin, chlorpyrifos and carbaryl. READ MORE

  4. 2. Ligands of the Angiotensin II Type 2 Receptor : Exploring structure and function of the AT2R ligand C38

    Author : Rebecka Isaksson; Mats Larhed; Annette Bayer; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Angiotensin II type 2 receptor; AT2R antagonists; sulfonyl carbamates; bicyclic amides; metabolic stability; functional activity assay; pharmacological profile; medicinal chemistry; structure-activity relationship; Medicinal Chemistry; Läkemedelskemi;

    Abstract : The renin-angiotensin-aldosterone-system (RAAS) control blood-pressure regulation, exerted by the main effector peptide angiotensin II (AngII) binding the angiotensin II type 1 receptor (AT1R). While hypertension is the most known disease caused by over-activity in RAAS, several proteins in the system exhibit protective functions. READ MORE

  5. 3. Kinetic studies of the decomposition of some carbamates, ureas and related cyclic compounds

    Author : Gudrun Ekberg; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PHARMACY; FARMACI;

    Abstract : .... READ MORE

  6. 4. Multicomponent Reactions in 11C/12C Chemistry : – Targeting the Angiotensin II Subtype 2 Receptor

    Author : Marc Stevens; Luke Odell; Mats Larhed; Gunnar Antoni; Sergio Estrada; Ola Åberg; Neil Vasdev; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; carbonylation; positron emission tomography; multicomponent reactions; AT2R; 3; 4-dihydroquinazolinone; sulfonyl azides; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : Section 1 of this thesis contains an introduction to method development in organic synthesis, multicomponent reactions, sulfonyl azides, tracer development in 11C chemistry and the biological target.Section 2 describes the use of sulfonyl azides in carbonylative chemistry. Paper I covers development of a diazotransfer protocol. READ MORE

  7. 5. Amidst the green Metal-catalyzed amide formation from carboxylic acids

    Author : Helena Lundberg; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : This thesis describes novel methods for transition metal-catalyzed transformation of non-activated carboxylic acids to amides. It was found that 2-10 mol% of zirconium(IV) chloride or 10-20 mol% titanium(IV) isopropoxide catalyzed the formation of a range of secondary and tertiary amides in good to excellent yields (61-99%) in THF at 70-100°C, with molecular sieves present as water scavengers. READ MORE