Search for dissertations about: "Carbapenem resistance"

Showing result 1 - 5 of 14 swedish dissertations containing the words Carbapenem resistance.

2. 1. Antibiotic resistance gone wild : A One Health perspective on carriage, selection and transmission of Extended-Spectrum Cephalosporinase- and Carbapenemase-producing Enterobacteriaceae

   Author : Clara Atterby; Josef D. Järhult; Nicola Williams; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Antibiotic resistance; E. coli; K. pneumoniae; ESBL; AmpC; Carbapenemase; ciprofloxacin resistance; colistin resistance; rural; wildlife; birds; sub-MIC; MSC; Cambodia; environment; epidemiology; Infektionssjukdomar; Infectious Diseases;

   Abstract : Antibiotics have saved millions of lives since they came into clinical use during the Second World War in the 1940s. Today, our effective use of antibiotics is under great threat due to emerging antibiotic resistance in bacteria. This thesis addresses the problems of antibiotic resistance from a ”One Health” perspective. READ MORE

4. 2. Mechanisms and Dynamics of Carbapenem Resistance in Escherichia coli

   Author : Marlen Adler; Linus Sandegren; Josep Casadesús; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; carbapenem; antibiotic resistance; fitness cost; ESBLs; penicillin-binding proteins; gene amplification;

   Abstract : The emergence of extended spectrum β-lactamase (ESBL) producing Enterobacteriaceae worldwide has led to an increased use of carbapenems and may drive the development of carbapenem resistance. Existing mechanisms are mainly due to acquired carbapenemases or the combination of ESBL-production and reduced outer membrane permeability. READ MORE

5. 3. Carbapenem resistance in Pseudomonas aeruginosa

   Author : Christian Giske; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Carbapenem (imipenem and meropenem) resistance in Pseudomonas aeruginosa is increasing, with global resistance rates approaching 20%. The most common resistance mechanisms are down-regulation of the porin OprD, and increased activity of multi-drug efflux pumps, primarily MexAB-OprM. READ MORE

6. 4. β-lactam combinations against multidrug-resistant Enterobacterales : Exploring combination effects and resistance development

   Author : Lisa Allander; Thomas Tängdén; Linus Sandegren; Pernilla Lagerbäck; Arnfinn Sundsfjord; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Gram-negative bacteria; antibiotic combination therapy; antibiotic resistance; beta-lactams; beta-lactamase inhibitors; Infektionssjukdomar; Infectious Diseases;

   Abstract : The β-lactam antibiotics are a cornerstone in treating bacterial infections, but the increasing prevalence of antibiotic resistance worldwide threatens their effectiveness. The main driver of β-lactam resistance is the production of β-lactamases, which are bacterial enzymes that inactivate the antibiotic. READ MORE

7. 5. Chromosomal antibiotic resistance mechanisms in Pseudomonas aeruginosa and Neisseria gonorrhoeae

   Author : Sohidul Islam; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The progressive increase in fluoroquinolone resistant N. gonorrhoeae and emergence of multiple antibiotic resistant P. aeruginosa are growing concerns among physicians and health policy makers. In N. READ MORE