Search for dissertations about: "Carbidopa"

Showing result 1 - 5 of 9 swedish dissertations containing the word Carbidopa.

  2. 1. New Approaches for Levodopa Treatment in Parkinson’s Disease

    Author : Marina Senek; Dag Nyholm; Elisabet I Nielsen; Maral Mouradian; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson’s disease; Pharmacokinetics; Pharmacodynamics; Population modeling; Levodopa; Carbidopa; Entacapone; Microtablets; Intestinal infusion;

    Abstract : Parkinson’s disease (PD) is characterized by degeneration of dopaminergic cells, which results in dopamine depletion. Levodopa is the most effective symptomatic treatment, however, disease progression along with the unfavorable pharmacokinetics of levodopa makes the disease increasingly difficult to treat with time. READ MORE

  4. 2. Levodopa pharmacokinetics -from stomach to brain : A study on patients with Parkinson’s disease

    Author : Maria Nord; Nil Dizdar; Jonas Lind; Peter Söderkvist; Filip Bergquist; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Parkinson’s disease (PD) is one of the most common neurodegenerative disorders and it is caused by a loss of dopamine (DA) producing neurons in the basal ganglia in the brain. The PD patient suffers from motor symptoms such as tremor, bradykinesia and rigidity and treatment with levodopa (LD), the precursor of DA, has positive effects on these symptoms. READ MORE

  5. 3. Intestinal transport of levodopa : Implications for the therapy of Parkinson's disease

    Author : Dag Nilsson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Parkinson s disease; levodopa. duodenal Infusion; intestinal permeability; positron emission tomography; Neurovetenskap; Neurology; Neurologi; Neurology; neurologi;

    Abstract : Levodopa has been the basic treatment of patients with Parkinson's disease for the last 30 years. However, with time nearly all patients develop fluctuations in motor performance correlated to levodopa plasma concentrations. READ MORE

  6. 4. Pharmacotherapy for Parkinson's Disease - Observations and Innovations

    Author : Dag Nyholm; Sten-Magnus Aquilonius; Andrew Lees; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Parkinson s disease; levodopa; pharmacokinetics; infusion; drug delivery systems; electronic patient diary; Neurovetenskap; Neurology; Neurologi; Neurology; Neurologi;

    Abstract : Pharmacotherapy for Parkinson’s disease (PD) is based on levodopa, the most effective dopaminergic drug. The development of motor complications constitutes the major challenge for new or refined therapies. READ MORE

  7. 5. The bioenergetic roles of PGC-1α1, kynurenines, and GPR35 in exercise and obesity

    Author : Shamim Dadvar; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Obesity is a major cause of medical comorbidity with detrimental effects on health span. Fundamentally, obesity is a condition of disrupted energy metabolism, where energy intake chronically exceeds expenditure. Over time, this disruption causes a systemic low-grade inflammation and impairs energy homeostasis. READ MORE