Search for dissertations about: "Carbohydrate Conformation"

Showing result 1 - 5 of 15 swedish dissertations containing the words Carbohydrate Conformation.

  2. 1. Structure, dynamics and reactivity of carbohydrates : NMR spectroscopic studies

    Author : Jerk Rönnols; Göran Widmalm; Mikael Bols; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Carbohydrates; Conformation; NMR spectroscopy; Hydrogen bond; organisk kemi; Organic Chemistry;

    Abstract : The main focus of this thesis is on the ring conformations of carbohydrate molecules; how the conformational equilibria and the rates of the associated interconversions are affected by the molecular constitution and their surroundings.The conformational equilibria of a group of amine linked pseudodisaccharides, designed as potential glycosidase inhibitors, comprising α-D-altrosides are described in Chapter 3. READ MORE

  4. 2. Structural Studies of O-antigen polysaccharides, Synthesis of 13C-labelled Oligosaccharides and Conformational Analysis thereof, using NMR Spectroscopy

    Author : Ulrika Olsson; Göran Widmalm; Corine Sandström; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NMR spectroscopy; conformation; Escherichia coli; lipopolysaccharide; O-antigen; carbohydrates; structure; isotopic labelling; Organic chemistry; Organisk kemi; Organic Chemistry; organisk kemi;

    Abstract : In order to understand biological processes, to treat and diagnose diseases, find appropriate vaccines and to prevent the outbreak of epidemics, it is essential to obtain more knowledge about carbohydrate structures. This thesis deals with structure and conformation of carbohydrates, analysed by NMR spectroscopy and MD simulations. READ MORE

  5. 3. Tales from the Sweet Side of Life : Structure and dynamics of carbohydrate-based systems

    Author : Alessandro Ruda; Göran Widmalm; Jesús Jiménez Barbero; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; carbohydrates; nuclear magnetic resonance; molecular dynamics; glycans; conformational analysis; structure elucidation; protein-glycan interactions; Organic Chemistry; organisk kemi;

    Abstract : The field of glycomics has experienced significant developments in the last few decades, revealing a profound and elaborate language behind the intrinsic complexity of the glycans structures. This ‘sugar code’ is at the basis of intercellular interaction and recognition. For this language to be understood, its chemical basis must be unveiled. READ MORE

  6. 4. Synthesis, structure and conformation of oligo- and polysaccharides

    Author : Andreas Larsson; Göran Widmalm; Laurence Mulard; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; Organisk kemi;

    Abstract : Carbohydrates are a complex group of biomolecules with a high structural diversity. Their almost omnipresent occurrence has generated a broad field of research in both biology and chemistry. This thesis focuses on three different aspects of carbohydrate chemistry, synthesis, structure elucidation and the conformational analysis of carbohydrates. READ MORE

  7. 5. Conformational Studies of Biologically Active Peptides

    Author : Björn Walse; Biofysikalisk kemi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; PapD chaperone; P pili; desmopressin; DDAVP; protein-peptide interactions; glycopeptides; peptide design; transferred NOE; molecular dynamics simulations; circular dichroism; peptide conformation; NMR spectroscopy; immunogenic glycopeptides; Physical chemistry; Fysikalisk kemi;

    Abstract : In this work conformational studies have been performed on peptides from four different systems in an attempt to gain knowledge about their biological function. Circular dichroism (CD) spectroscopy and nuclear magnetic resonance (NMR) spectroscopy in combination with distance geometry and restrained molecular dynamics simulations were the methods used. READ MORE