Search for dissertations about: "Carbonylation"

Showing result 1 - 5 of 33 swedish dissertations containing the word Carbonylation.

  1. 1. Exploring Palladium-Mediated 11C/12C-Carbonylation Reactions PET Tracer Development Targeting the Vesicular Acetylcholine Transporter

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Sara Roslin; Uppsala universitet.; [2017]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Carbonylation; palladium; carbon-11; radiochemistry; positron emission tomography; vesicular acetylcholine transporter; vesamicol; alkyl halide; oxidative carbonylation; acylamidine; oxadiazole; heterocycle; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : The work presented herein describes the utilization and exploration of palladium-mediated incorporations of carbon monoxide and/or [11C]carbon monoxide into compounds and structural motifs with biological relevance.The first part of the thesis describes the design, synthesis and 11C-labeling of prospective PET tracers for the vesicular acetylcholine transporter (VAChT), a target affected in several neurodegenerative diseases. READ MORE

  2. 2. Palladium-Catalyzed Carbonylation and Arylation Reactions

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Jonas Sävmarker; Uppsala universitet.; [2012]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; palladium; carbonylation; styrene; amidine; aryl ketones; aryl sulfinates; ESI-MS; aryltrifluoroborates; Organic Pharmaceutical Chemistry; Organisk farmaceutisk kemi;

    Abstract : Palladium-catalyzed reactions have found widespread use in contemporary organic chemistry due to their impressive range of functional group tolerance and high chemo- and regioselectivity. The pioneering contributions to the development of the Pd-catalyzed C-C bond forming cross-coupling reaction were rewarded with the Nobel Prize in Chemistry in 2010. READ MORE

  3. 3. Photoinitiated Radical Carbonylation Using [11C]Carbon Monoxide 11C-Labelling of Aliphatic Carboxylic Acids, Esters, and Amides

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Oleksiy Itsenko; Uppsala universitet.; [2005]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; 11C-labelling; radicals; carbonylation; carbon monoxide; solvent effects; sensitizers; sulfoxides; WAY-100635; PET; Organisk kemi; NATURAL SCIENCES Chemistry Organic chemistry; NATURVETENSKAP Kemi Organisk kemi;

    Abstract : One-step photoinitiated free radical carbonylation was employed for the rapid (5–7 min) labelling of aliphatic carboxylic acids, esters, and amides with a short-lived positron emitter 11C (t½ = 20.3 min) at the carbonyl position. The labelled compounds were synthesized from alkyl iodides (0.05–0. READ MORE

  4. 4. Synthesis of 11C-labelled Alkyl Iodides Using Non-thermal Plasma and Palladium-mediated Carbonylation Methods

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Jonas Eriksson; Uppsala universitet.; [2006]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; isotopic labelling; carbon-11; alkyl iodides; acrylamides; specific radioactivity; carbonylation; carbon monoxide; non-thermal plasma; PET; Organisk kemi;

    Abstract : Compounds labelled with 11C (β+, t1/2 = 20.4 min) are used in positron emission tomography (PET), which is a quantitative non-invasive molecular imaging technique. It utilizes computerized reconstruction methods to produce time-resolved images of the radioactivity distribution in living subjects. READ MORE

  5. 5. [11C]Carbon Monoxide and Aryl Triflates in Palladium-Mediated Carbonylation Reactions Synthetic approaches to [11C]Carbonyl Compounds and [11C]Amines

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Obaidur Rahman; Uppsala universitet.; [2004]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; [11C]Carbon monoxide; Aryl triflates; Carbonylation; Organisk kemi; NATURAL SCIENCES Chemistry Organic chemistry; NATURVETENSKAP Kemi Organisk kemi;

    Abstract : The usefulness of low concentrations (typically 10 to 100 µM) of [11C]carbon monoxide and aryl triflates as substrates in 11C-carbonylation using different nucleophiles in the presence of lithium bromide was investigated. The reactions were performed in a micro autoclave of 200 µL volume and catalysed (mediated) by palladium(0). READ MORE