Search for dissertations about: "Carl Blomqvist"

Showing result 1 - 5 of 7 swedish dissertations containing the words Carl Blomqvist.

  1. 1. Cyclin A and cyclin E as prognostic factors in early breast cancer

    Author : Cecilia Ahlin; Marie-Louise Fjällskog; Carl Blomqvist; Göran Landberg; Uppsala universitet; []
    Keywords : Oncology; breast cancer; chemotherapy; cyclin A; cyclin E; aberrant cyclin E; Ki-67; TMA; Onkologi;

    Abstract : Breast cancer is one of the most common malignancies in women. Due to early detection and the use of screening programs approximately 60% of all new cases lack lymph node involvement. Today, a substantial proportion of these women will be offered adjuvant systemic chemotherapy. READ MORE

  2. 2. Individually Tailored Toxicity-based Chemotherapy : Studies on Patients with Primary and Metastatic Breast Cancer

    Author : Henrik Lindman; Jonas Bergh; Carl Blomqvist; Peter Nygren; Bo Nordenskjöld; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; breast cancer; tailored chemotherapy; toxicity-based dosing; high-dose therapy; MR imaging; G-CSF; epirubicin; docetaxel; cyclophosphamide; 5-fluorouracil; Onkologi; Oncology; Onkologi;

    Abstract : Standard dosing of chemotherapy based on body surface area (BSA) results in large individual differences in toxicity due to a large inter-patient variability in pharmacokinetics (PK) and pharmacodynamics (PD). This results in under-dosing in certain patients with a potentially weaker antitumoral effect. READ MORE

  3. 3. Multicellular Tumour Spheroids in a Translational PET Imaging Strategy

    Author : Azita Monazzam; Mats Bergström; Carl Blomqvist; Jörgen Carlsson; Raymond Josephsson; Eric O Aboagye; Uppsala universitet; []
    Keywords : Oncology; Positron Emission Tomography; Multicellular Tumour Spheroid; Translational Research; Onkologi;

    Abstract : Positron Emission Tomography (PET) has gained an important roll in clinical for diagnosis, staging and prognosis of a range of cancer types. Utilization of PET for monitoring and evaluation of cancer treatment is an attractive but almost new concept. The proper choice of PET-tracer as a biomarker for treatment follow-up is crucial. READ MORE

  4. 4. Cardiovascular Side Effects of Radiotherapy in Breast Cancer

    Author : Greger Nilsson; Carl Blomqvist; Lars Holmberg; Anne Hansen Ree; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast Cancer; Radiotherapy; Cardiovascular; Stroke; Coronary artery stenosis; Coronary artery disease; Oncology; Onkologi;

    Abstract : The aim of the thesis was to study cardiovascular side effects of radiotherapy (RT) in breast cancer (BC).In a study base of 25,171 women with BC diagnosed 1970-2000, we found a statistically significant 12% increase of stroke, compared to the stroke incidence in the background population. READ MORE

  5. 5. Chemosensitivity in Breast Cancer

    Author : Kenneth Villman; Carl Blomqvist; Ulf Tidefelt; Nils Wilking; Uppsala universitet; []
    Keywords : Oncology; breast cancer; chemotherapy; anthracycline; predictive; topoisomerase; TOP2A; HER2; cyclin A; in vitro; Onkologi;

    Abstract : Breast cancer mortality in Sweden is now in decline, thanks to early detection and the wide use of adjuvant endocrine therapy and chemotherapy. While hormone receptor status is predictive of response to endocrine treatment, there is no clinically useful predictive marker of a patient’s response to chemotherapy. READ MORE