Search for dissertations about: "Carl-fredrik Mandenius"

Showing result 1 - 5 of 10 swedish dissertations containing the words Carl-fredrik Mandenius.

  1. 1. Exploring the SPR methodology for monitoring of critical attributes in toxicity testing and bioproduction

    Author : Gunnar Bergström; Carl-Fredrik Mandenius; Bengt Danielsson; Linköpings universitet; []
    Keywords : ;

    Abstract : Analysis of biological components is central in bioprocess monitoring, process control, product quality control and cell based toxicity assaying. One of these themes that is pursued in this thesis is the use of biosensors for monitoring of molecular markers, exploiting the natural selectivity of biomolecules. READ MORE

  2. 2. Microfluidic biosensor systems for cardiotoxicity assaying

    Author : Gunnar Bergström; Carl-Fredrik Mandenius; Nate Robinson; Staffan Nilsson; Linköpings universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP;

    Abstract : Toxicity screening is an important part of pharmaceutical development and early detection of toxic side effects provide the opportunity for early redesign or termination of unfeasible projects. Today toxicity testing is relying on experiments on animals. READ MORE

  3. 3. Organs-on-chips for the pharmaceutical development process : design perspectives and implementations

    Author : Jonas Christoffersson; Carl-Fredrik Mandenius; Danny van Noort; Peter Sartipy; Linköpings universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Organs-on-chips; cell culture models; pharmaceutical development; microfluidics;

    Abstract : Organs-on-chips are dynamic cell culture devices created with the intention to mimic organ function in vitro. Their purpose is to assess the toxicity and efficacy of drugs and, as early as possible in the pharmaceutical development process, predict the outcome of clinical trials. READ MORE

  4. 4. Operator Training Simulators towards Industrial Biotechnology

    Author : Inga Gerlach; Carl-Fredrik Mandenius; Volker C. Hass; Carl Johan Franzén; Linköpings universitet; []
    Keywords : ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY;

    Abstract : Biotechnological processes are carried out by applying advanced and demanding process strategies. Thus, fundamental understanding and knowledge about the applied microorganism is required to achieve high productivity and profitability. READ MORE

  5. 5. Development of soft sensors for monitoring and control of bioprocesses

    Author : Robert Gustavsson; Carl-Fredrik Mandenius; Johan Hyllner; Carl Johan Franzén; Linköpings universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY;

    Abstract : In the manufacture of bio-therapeutics the importance of a well-known process is key for a high product titer and low batch to batch variations. Soft sensors are based on the concept that online sensor signals can be used as inputs to mathematical models to derive new valuable process information. READ MORE