Search for dissertations about: "Carl-magnus Bäckesjö"

Found 1 swedish dissertation containing the words Carl-magnus Bäckesjö.

2. 1. Molecular biology of Brouton's tyrosine kinase

   Author : Carl-Magnus Bäckesjö; Karolinska Institutet; Karolinska Institutet; []
   Keywords : X-linked agammaglobulinemia; XLA; Bruton s tyrosine kinase; Btk; signal transduction; phosphorylation; pleckstrin homology domain; PH; SH2; SH3.;

   Abstract : X-linked agammaglobulinemia (XLA) is caused by an arrest in the B lymphocyte differentiation. XLA patients lack mature B-cells and subsequently antibody production. The defective gene causing XLA is the BTK gene, which codes for the protein Bruton s tyrosine kinase (Btk), a cytoplasmic enzyme related to the Src family of kinases. READ MORE