Search for dissertations about: "Casein kinase"

Showing result 1 - 5 of 7 swedish dissertations containing the words Casein kinase.

  2. 1. Assessment of therapeutic targets in experimental models of Myc-induced lymphoma

    Author : Linus Plym Forshell; Jonas Nilsson; Lars-Gunnar Larsson; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer; Myc; Decitabine; Pim kinase; RCAS-tva; Neurobiology; Neurobiologi; molekylärbiologi; Molecular Biology;

    Abstract : The Myc transcription factor activates expression of genes that promote cellular functions such as proliferation and cell growth. The deregulated Myc expression, characteristic for the tumor cell, also activates apoptosis, which selects for additional genetic changes deactivating the induced cell death. READ MORE

  4. 2. Studies of calcium binding proteins 1 and 2 and protein kinase CK2

    Author : Inger Janson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; calcium binding protein 1; calcium binding protein 2; calcium binding protein 4; erd2receptor; protein kinase CK2; endoplasmic reticulum; Golgi; microsomes; heparin; Biokemi; Biochemistry; Biokemi; Medical and Physiological Chemistry; medicinsk och fysiologisk kemi;

    Abstract : The endoplasmic reticulum (ER) is a major intracellular compartment of eukaryotic cells and is the site of the synthesis and post-translational modification of both secretory and membrane glycoproteins. Upon cell rupture vesicles of several kinds are formed from cell membranes, mainly derived from ER and are called microsomes. READ MORE

  5. 3. STAT5 expression and regulation in mammary epithelial cells

    Author : Hanne Olsen; Karolinska Institutet; Karolinska Institutet; []
    Keywords : STAT5; JAK2; PPAR-gamma; ER; MAPK; mammary epithelial cell differentiation;

    Abstract : The mammary gland of an adult mammal undergoes cycles of proliferation and differentiation influenced by growth factors, peptide, and steroid hormones, e.g. epidermal growth factor (EGF), prolactin (PRL) and estrogen (E). READ MORE

  6. 4. Free-energy studies of ligand-binding affinities

    Author : Vilhelm Ekberg; Beräkningskemi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; free energy perturbation; drug design; ligand-binding affinity; entropy; molecular mechanics; molecular dynamics;

    Abstract : In drug discovery, it is of utmost importance to accurately calculate the free energies of binding ligands to various protein targets, such as enzymes and receptors. We have assessed and used computational tools for this aim, most of them based on molecular dynamics (MD) simulations. READ MORE

  7. 5. Proteome profiling of human breast cancer

    Author : Olena Zakharchenko; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Breast cancer (BC) takes thousands of woman’s lives yearly. Several factors have been found to influence initiation and development of breast cancer, and to affect prognosis and treatment of this disease. READ MORE