Search for dissertations about: "Caspases: metabolism"

Showing result 1 - 5 of 8 swedish dissertations containing the words Caspases: metabolism.

  1. 1. Connecting viral oncoproteins to microRNA, autophagy and metabolism in Merkel cell carcinoma

    Author : Satendra Kumar; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : Merkel cell carcinoma (MCC) is an aggressive type of skin cancer. Around 80% of MCCs harbor an integrated Merkel cell polyomavirus (MCPyV) genome with a mutation in the large T antigen (LT) gene, leading to expression of truncated LT. It is evident that the viral truncated LT and small T antigen (sT) play important roles in MCC tumorigenesis. READ MORE

  2. 2. The role of autophagy in cartilage physiology and metabolism : implications for growth and ageing

    Author : Karuna Kumari Vuppalapati; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : Cartilage is the main constituent of the embryonic skeleton. At the ends of long bones cartilage forms a growth plate consisting of chondrocytes in distinct stages of differentiation and arranged into three zones. These chondrocytes mediate linear bone growth through synchronized proliferation, differentiation, and production of matrix. READ MORE

  3. 3. Studies on caspase signaling in microglia

    Author : Johanna Rodhe; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : The aim of this thesis is to investigate the roles of caspase-8 and caspase-3 in microglia and in brain disorders, beyond their function in apoptosis. Microglia are resident immune cells of the central nervous system and act as the first line of defense against invading pathogens and other types of brain insults. READ MORE

  4. 4. Experimental Studies of Ursolic Acid and Alkaline Sphingomyelinase in Colon Cancer and Colitis

    Author : David Andersson; Lund Medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Sphingomyelin (SM) is a sphingolipid present in all eukaryotic cell membranes. Hydrolysis of SM by sphingomyelinase (SMase) generates ceramide, which has effects on cell-cycle regulation and apoptosis. READ MORE

  5. 5. Mitochondria in Alzheimer disease : regulatory mechanisms and cell death

    Author : Louise Hedskog; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : Synaptic loss is the major correlate for cognitive decline in Alzheimer disease (AD). Processes taking place in the synapses are highly energy demanding and needs strict regulation, which makes the mitochondria and ER crucial at these sites so as to supply energy and spatially regulate intracellular calcium signaling. READ MORE