Search for dissertations about: "Cathepsin"

Showing result 1 - 5 of 82 swedish dissertations containing the word Cathepsin.

  2. 1. Cellular Uptake of Cystatin C. Subcellular localisation and intracellular effects of a secreted cysteine protease inhibitor

    Author : Hanna Wallin; Avdelningen för klinisk kemi och farmakologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cathepsin; cell line; co-localisation; cystatin C; internalisation; legumain;

    Abstract : Cystatin C is a cysteine protease inhibitor, aimed for secretion, as it is produced with a signal peptide. Its target enzymes are thought to be the lysosomal cysteine cathepsins and legumain. READ MORE

  4. 2. Regulation of UV induced apoptosis in human melanocytes

    Author : Cecilia Bivik; Inger Rosdahl; Karin Öllinger; Maria Shoshan; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; apoptosis; UV; melanocyte; lysosome; cathepsin; Bcl-2; Bax; Hsp70; JNK; Dermatology and venerology; Dermatologi och venerologi;

    Abstract : Malignant melanoma arises from the pigment producing melanocytes in epidermis and is the most aggressive type of skin cancer. The incidence of malignant melanoma is increasing faster than any other type of cancer in white population worldwide, with a doubling rate every 10-20 years. READ MORE

  5. 3. Amyotrophic Lateral Sclerosis – A Study in Transgenic Mice

    Author : Hanna Wootz; Dan Lindholm; Håkan Aldskogius; Christopher Fowler; Uppsala universitet; []
    Keywords : Neurosciences; ALS; Caspase; Caspase-12; Cathepsin; Cystatin; ER stress; Motor neuron; Neurodegeneration; Sod1; XIAP; Neurovetenskap;

    Abstract : Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with an incidence of 1.5-2.7/100000 people/year. Today there is no cure for the disease and only symptomatic treatments are available. READ MORE

  6. 4. Amyloid β-protein, Cystatin C and Cathepsin B as Biomarkers of Alzheimer's Disease

    Author : Johan Sundelöf; Lars Lannfelt; Lena Kilander; Hans Basun; Johan Sundstrom; Laura Fratiglioni; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer´s disease; amyloid β-protein; cystatin C; cathepsin B; biomarkers; risk factors; epidemiology; Geriatrics and medical gerontology; Geriatrik och medicinsk gerontologi; Medicin; Medicine;

    Abstract : It is suggested that Alzheimer’s disease (AD) is caused by an imbalance between production, degradation and clearance of the amyloid-β (Aβ) protein. This imbalance leads to aggregation of Aβ and tau proteins and neurodegeneration in the brain. READ MORE

  7. 5. Cathepsin S as a Biomarker of Low-grade Inflammation, Insulin Resistance, and Cardiometabolic Disease Risk

    Author : Elisabeth Jobs; Johan Ärnlöv; Erik Ingelsson; Ulf Risérus; Göran Bergström; Uppsala universitet; []
    Keywords : epidemiology; cathepsin S; inflammation; insulin resistance; diabetes; mortality; cardiovascular mortality; cancer mortality; healthy Nordic diet.; Hälsa och välfärd;

    Abstract : Cathepsin S is a protease important in major histocompatibility complex (MHC) class II antigen presentation and also in degrading the extracellular matrix. Studies, most of them experimental, have shown that cathepsin S is involved in different pathological conditions such as obesity, inflammation, atherosclerosis, diabetes, and cancer. READ MORE