Search for dissertations about: "Cdc25A"

Showing result 1 - 5 of 7 swedish dissertations containing the word Cdc25A.

  2. 1. Growth control mechanisms in normal and neoplastic mammalian cells

    Author : Mozhgan Afrakhte; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; PDGF-AA; TGF-beta; Inhibitory SMADs; Growth inhibition; CDK; CKI; Cdc25A; Genetik; Clinical genetics; Klinisk genetik; Genetics; genetik;

    Abstract : The main theme of the studies presented in this thesis is, the growth control mechanisms whose loss in normal cells predispose to or cause cancer. The balance between growth inhibitory and stimulatory mechanisms is crucial for the development and maintenance of a normal animal. READ MORE

  4. 2. Regulation of CDK dephosphorylation in mitotic entry

    Author : Arne Lindqvist; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cell cycle progression is orchestrated by the activity of a Cyclin dependent kinase (Cdk) in complex with a Cyclin. The key regulator of early mitotic events is the Cyclin B1/Cdk1 complex. In G2, Cyclin B1/Cdk1 is kept inactive by phosphorylation in the active site of Cdk1. READ MORE

  5. 3. The ABC of the cell cycle : roles of the mammalian Cdc25 isoforms

    Author : Andreas Lundgren; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cell cycle progression is mediated by Cyclin dependent kinases (Cdks) in complex with Cyclins. The activity of the Cyclin-Cdk complexes is regulated through a variety of levels: expression and proteolysis of Cyclins, binding of inhibitors, phosphorylations and subcellular localization. READ MORE

  6. 4. Exposure to xenobiotic chemicals disrupts metabolism, rhythmicity and cell proliferation in Drosophila melanogaster

    Author : Hao Cao; Helgi B. Schiöth; Michael J. Williams; Jan Larsson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; xenobiotics; metabolism; insulin signalling; circadian rhythm; carcinogen; Biomedical Laboratory Science; Biomedicinsk laboratorievetenskap;

    Abstract : Most species are constantly exposed to xenobiotic chemicals through multiple routes. Among all categories of xenobiotics, phthalates and bisphenols are two of the most widely used plasticizers and can be found in polyvinyl chloride (PVC) materials, medical devices and even drinking water. READ MORE

  7. 5. Antiproliferative action of estrogen receptor beta and Hes-1 in breast cancer

    Author : Johan Hartman; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Breast cancer is the most common malignancy among Swedish women. Although the mechanism behind the tumorigenesis remains unclear, estrogen receptor a (ERa) plays an important role in the progression of breast cancer and is regarded as a target for endocrine therapy. READ MORE