Search for dissertations about: "Cdk₁"

Showing result 1 - 5 of 16 swedish dissertations containing the word Cdk₁.

  2. 1. Signaling pathways in the development of female germ cells

    Author : Deepak Adhikari; Kui Liu; Elisabet Stener-Victorin; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; ovary; primordial follicle; activation; mTORC₁; PI₃K; oocyte maturation; MPF; Cdk₁; medicinsk biokemi; Medical Biochemistry;

    Abstract : Primordial follicles are the first small follicles to appear in the mammalian ovary. Women are born with a fixed number of primordial follicles in the ovaries. Once formed, the pool of primordial follicles serves as a source of developing follicles and oocytes. READ MORE

  4. 2. Regulation of CDK dephosphorylation in mitotic entry

    Author : Arne Lindqvist; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cell cycle progression is orchestrated by the activity of a Cyclin dependent kinase (Cdk) in complex with a Cyclin. The key regulator of early mitotic events is the Cyclin B1/Cdk1 complex. In G2, Cyclin B1/Cdk1 is kept inactive by phosphorylation in the active site of Cdk1. READ MORE

  5. 3. Regulation of normal and cancer cells as a base for cell cycle-targeted therapy

    Author : Regina Miftakhova; Malmö Experimentell cancerforskning; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell cycle regulation; cyclin A1; stem cells; stem cell niche; epigenetics; cancer;

    Abstract : The majority of current treatments used for treatment of prostate cancer (PCa) and leukemia are often limited to a narrow subsets of treated patients. As such, there still remains a significant scope for gaining deeper understanding of molecular mechanisms underlying cancer metastasis for improvement of targeted treatment. READ MORE

  6. 4. The ABC of the cell cycle : roles of the mammalian Cdc25 isoforms

    Author : Andreas Lundgren; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cell cycle progression is mediated by Cyclin dependent kinases (Cdks) in complex with Cyclins. The activity of the Cyclin-Cdk complexes is regulated through a variety of levels: expression and proteolysis of Cyclins, binding of inhibitors, phosphorylations and subcellular localization. READ MORE

  7. 5. Disassembly and reassembly of the nuclear pore complex

    Author : Evgeny A. Onischenko; Einar Hallberg; Paul R. Clarke; Södertörns högskola; Karolinska Institutet; Karolinska Institutet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : The nuclear pore complexes (NPCs) are multiprotein communicative channels spanning the nuclear envelope. In higher eukaryotes NPCs reversibly disassemble during mitosis into distinct nucleoporin subcomplexes. Some cell types (e.g. READ MORE