Search for dissertations about: "Cell Differentiation drug effects"

Showing result 1 - 5 of 54 swedish dissertations containing the words Cell Differentiation drug effects.

2. 1. The Effects of Genetic and Epigenetic Variation on Human Pluripotent Stem Cell Differentiation

   Author : Roksana Moraghebi; Avdelningen för molekylärmedicin och genterapi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Abstract : Human pluripotent stem cells (PSCs) are widely used for studying embryonic development, disease modelling, drug discovery and cell therapy development. Using human PSCs as a model has significantly contributed to our understanding of embryonic development and elucidating novel pathological mechanisms as well as developing new drugs. READ MORE

4. 2. Heparan sulfate dependent cell signaling and associated pathophysiology : Implications in tumorigenesis and embryogenesis

   Author : Tahira Batool; Jin-Ping Li; Aristidis Moustakas; Liliana Schaefer; Ingvar Ferby; Michael Welsh; Anders Malmström; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Heparanase; Glucuronyl-C5 epimerase; Heparan Sulfate; Heparin; Lung Cancer; Cancer cell Singling; TGF-Beta; BMP; VEGF; Notch Signaling; Tumor growth; Metastasis; embryonic development; Medical Biochemistry; Medicinsk biokemi;

   Abstract : Heparan sulfate proteoglycans (HSPGs) consist of a protein core to which several linear, negatively charged heparan sulfate (HS) chains are covalently attached. HSPGs are expressed on the cell surface and in the extra-cellular matrix (ECM) where they have diverse biological functions, for example co-receptor functions. READ MORE

5. 3. A long and winding road: Differentiating human embryonic stem cells into dopaminergic neurons

   Author : Oktar Guloglu; Institutionen för experimentell medicinsk vetenskap; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; adipocyte; PA6; DZNEP; dopaminergic differentiation; embryonic stem cells;

   Abstract : Parkinson’s disease is a progressive neurodegenerative disorder. Since the motor manifestations of the disease is associated with the loss of dopaminergic (DAergic) neurons in the substantia nigra pars compacta, cell replacement therapy is a promising approach for treatment. READ MORE

6. 4. p63 – from expression to function : studies of normal oral mucosa and squamous cell carcinoma of the head and neck

   Author : Niklas Thurfjell; Karin Nylander; Phillip Coates; Göran Roos; Luisa Guerrini; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; p63; SCCHN; p53; BRCA1; Pathology; Patologi;

   Abstract : The human p63 gene discovered in 1997 encodes a series of protein isoforms that differ in their N- and/or C-terminal sequences. These isoforms have widely differing properties in promoting or repressing p53-related functions such as growth arrest and apoptosis. READ MORE

7. 5. Preclinical investigation of novel therapies against neuroblastoma

   Author : Karin Hansson; Avdelningen för translationell cancerforskning; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer; Neuroblastoma; Translational research; Preclinical drug evaluation;

   Abstract : Neuroblastoma is a childhood tumor of the sympathetic nervous system and the most common tumor form diagnosed in infants. Patients with aggressive tumors are treated intensely with multi-modal therapy including chemotherapy, surgery, radiotherapy and immunotherapy. READ MORE