Search for dissertations about: "Cell and molecular biology"
Showing result 6 - 10 of 1811 swedish dissertations containing the words Cell and molecular biology.
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6. Molecular and Cellular Complexity of Glioma : Highlights on the Double-Edged-Sword of Infiltration Versus Proliferation and the Involvement of T Cells
Abstract : Glioblastoma multiforme (GBM), the most common and malignant brain tumor, is characterized by high molecular and cellular heterogeneity within and among tumors. Parameters such as invasive growth, infiltration of immune cells and endothelial proliferation contribute in a systemic manner to maintain the malignancy. READ MORE
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7. High-throughput screening using multicellular tumor spheroids to reveal and exploit tumor-specific vulnerabilities
Abstract : High-throughput drug screening (HTS) in live cells is often a vital part of the preclinical anticancer drug discovery process. So far, two-dimensional (2D) monolayer cell cultures have been the most prevalent model in HTS endeavors. However, 2D cell cultures often fail to recapitulate the complex microenvironments of in vivo tumors. READ MORE
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8. Studies on the Role of Apoptosis in Kidney Diseases
Abstract : Apoptosis is one of the most common types of cell death. Under physiological conditions, it plays an essential role in removal of damaged and potentially harmful cells. Excessive apoptosis has however been linked to a number of diseases including proteinuric kidney disease and DKD, and is believed to enhance the disease progression. READ MORE
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9. The receptor tyrosine kinase Met and the protein tyrosine phosphatase PTPN2 in breast cancer
Abstract : Breast cancer is the most common form of cancer in women worldwide and the second leading cause of cancer death. It is a heterogeneous disease and is subdivided into different subtypes, all with different treatment responses and survival outcomes. READ MORE
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10. Functional organisation of the cell nucleus in the fission yeast, Schizosaccharomyces pombe
Abstract : In eukaryotes the genome adopts a non-random spatial organisation, which is important for gene regulation. However, very little is known about the driving forces behind nuclear organisation. READ MORE