Search for dissertations about: "Cell specific perfusion rate"

Found 5 swedish dissertations containing the words Cell specific perfusion rate.

  2. 1. Tools for the development of intensified perfusion processes for mammalian cell culture

    Author : Hubert Schwarz; Véronique Chotteau; Mark Smales; KTH; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Recombinant protein biomanufacturing; Perfusion process; Integrated continuous bioprocessing; Monoclonal antibody; Erythropoietin; Chinese Hamster Ovary cells; Human Embryonic Kidney cells; Perfusion medium optimization; Cell specific perfusion rate; Raman spectroscopy; N-glycosylation; Microbioreactors; Design of Experiments; Biotechnology; Bioteknologi;

    Abstract : Recombinant protein therapeutics have become an indispensable part of modern medicine to treat a wide variety of diseases. Their manufacture is mostly based on mammalian cells with fed-batch production bioreactors and downstream batch purification unit operations. READ MORE

  4. 2. High cell density perfusion process development for antibody producing Chinese Hamster Ovary cells

    Author : Ye Zhang; Vincent Bulone; Veronique Chotteau; Carl-Fredrik Mandenius; KTH; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; WAVE Bioreactor; Cellbag; ATF; TFF; hollow fiber; CSPR; CellTank; SUB; single-use-bioreactor; disposable; perfusion rate; Biotechnology; Bioteknologi;

    Abstract : Perfusion operation mode is currently under fast expansion in mammalian cell based manufacturing of biopharmaceuticals, not only for labile drug protein but also for stable proteins such as monoclonal antibodies (mAbs). Perfusion mode can advantageously offer a stable cell environment, long-term production with high productivity and consistent product quality. READ MORE

  5. 3. Imaging the tumor microenvironment : the dynamics and modification of hypoxia

    Author : Anna Ljungkvist; Peggy L. Olive; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Radiology; tumor microenvironment; double hypoxic marker method; proliferation; hypoxia; hypoxic half-life; Radiologisk forskning; Radiological research; Radiologisk forskning; diagnostisk radiologi; Diagnostic Radiology;

    Abstract : The tumor vasculature is poor and heterogeneous which may result in inadequate oxygenation and changed energy status. In addition the balance between cell proliferation and the rate of cell death is disturbed, which results in tumor growth. READ MORE

  6. 4. Making endothelial cells move : a study of angiomotin and binding partners

    Author : Nathalie Luna Persson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Angiogenesis is a process crucial for tumor growth and metastasis formation and encompasses the control of endothelial directional migration, anastomosis and lumen formation. We have previously shown that Angiomotin (Amot), a membrane-associated scaffold protein, plays an essential role in controlling endothelial cell migration and cellshape. READ MORE

  7. 5. Pregnancy rhinitis : pathophysiological effects of oestrogen and treatment with oral decongestants

    Author : Karin Toll; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Pregnancy rhinitis, a common condition, is thought to affect about 20 % of pregnant women. This type of rhinitis may develop at any time during pregnancy and the nasal stuffiness usually disappears shortly after delivery. This condition is troublesome and can interfere with sleep, induce tiredness and dryness of the mouth. READ MORE