Search for dissertations about: "Cell-Matrix Adhesion"

Showing result 1 - 5 of 13 swedish dissertations containing the words Cell-Matrix Adhesion.

2. 1. Cell-matrix interactions : master regulators of cancer cell fate?

   Author : Sara Göransson; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The development and homeostasis of a multicellular organism require fundamental biological processes like cell proliferation, cell differentiation, cell migration, and controlled cell death. The extracellular matrix (ECM) guides many of these functions, via cell-matrix interactions that function as mechanical and biochemical signaling hubs. READ MORE

4. 2. The mechanism of integrin inactivation and cell signalling induced by c-erbB2, an oncogenic growth factor receptor

   Author : Shahram Hedjazifar; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; c-erbB2; integrin á2â1; cell-matrix; integrin conformation; PKB; ERK; Rho; ILK; Nck-2;

   Abstract : Overexpression of the oncogenic growth factor receptor, c-erbB2, is linked with poor prognosis in breast carcinomas and is used as a target for therapeutic strategies. To elucidate the mechanism underlying the tumorigenic action of an elevated c-erbB2 level, leading to homodimerization and activation, we have used an inducible system where a hybrid receptor consisting of the cytoplasmic and transmembrane domains of c-erbB2 fused to the extracellular domain of the trkA NGF receptor has been stably transfected into an immortalized mammary epithelial cell line. READ MORE

5. 3. Effects of invasin and YopH of Yersinia pseudotuberculosis on host cell signaling

   Author : Anna Gustavsson; Maria Fällman; Arnoud Sonnenberg; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; β1-integrin; Yersinia pseudotuberculosis; Invasin; YopH; Cell-Matrix Adhesion; Filopodia; Cell Spreading; Molekylärbiologi; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

   Abstract : Integrins are a large family of membrane-spanning heterodimeric (αβ) receptors that bind to ligands on other cells or to extracellular matrix (ECM) proteins. These receptors mediate bidirectional signaling over the cell membrane to induce signaling cascades mediating functions as cell adhesion, spreading and migration. READ MORE

6. 4. Laminin G Domains, their Receptors, and Activation of Intracellular Pathways

   Author : Hao Yu; Klinisk minnesforskning; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biomedicinska vetenskaper allmänt ; General biomedical sciences; cell-matrix interaction; signaling; receptor; Basement membrane; laminin;

   Abstract : Basement membranes are sheet like structures underlying epithelial, endothelial, adipocytes, muscle and peripheral nerve cells. Laminins are an important family of basement membrane proteins implicated in various biological functions through their interactions with cell surface receptors. Laminins are trimers composed of a, b and g chains. READ MORE

7. 5. Regulation of the cytoskeleton and the adhesiveness of intestinal epithelial cells by leukotriene D4

   Author : Ramin Massoumi; Institutionen för translationell medicin; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; oncology; Cytology; patologisk anatomi; Patologi allmän ; pathological anatomy; General pathology; PKC; vinculin; actin filament; focal adhesion; LTD4; integrin; cancerology; Cytologi; onkologi; cancer; Biochemistry; Metabolism; Biokemi; metabolism;

   Abstract : Leukotrienes belong to a family of biologically active conjugated trienes that are formed from arachidonic acid via the 5-lipoxygenase pathway and are important mediators of inflammatory reactions. The CysLT1 receptor that specifically serves as receptor for leukotriene D4 (LTD4) has been identified as a G-protein coupled receptor. READ MORE