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Showing result 1 - 5 of 83 swedish dissertations matching the above criteria.

2. 1. Effects of industrial solvent interactions : studies of behavioral effects in man

   Author : Anders Iregren; Stockholms universitet; []
   Keywords : SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Centrala nervsystemet; Lösningsmedel;

   Abstract : .... READ MORE

4. 2. Mesenchymal stem cells for repair of the peripheral and central nervous system

   Author : Maria Brohlin; Mikael Wiberg; Martin Birchall; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Bone marrow-derived stromal cells; Schwann cells; Peripheral nerve injury; Spinal cord injury; Neurotransplantation; anatomi; Human Anatomy; cell research; cellforskning;

   Abstract : Bone marrow-derived mesenchymal stem cells (MSC) have been shown to provide neuroprotection after transplantation into the injured nervous system. The present thesis investigates whether adult human and rat MSC differentiated along a Schwann cell lineage could increase their expression of neurotrophic factors and promote regeneration after transplantation into the injured peripheral nerve and spinal cord. READ MORE

5. 3. Studies of the Biology of Intrathecal Treatment in Progressive MS

   Author : Joakim Bergman; Anders Svenningsson; A. Tommy Bergenheim; Jonathan D. Gilthorpe; Joachim Burman; Magnus Andersson; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Progressive Multiple Sclerosis; intrathecal treatment; Ommaya reservoir; anti-CD20 therapy; microdialysis; cerebrospinal fluid; CNS compartments; Progressiv Multipel Skleros; intratekal behandling; Ommaya reservoar; anti-CD20 terapi; mikrodialys; ryggmärgsvätska; sektioner i centrala nervsystemet; Neurology; neurologi;

   Abstract : Background: Multiple Sclerosis (MS) is a chronic, inflammatory, autoimmune disease, affecting the central nervous system (CNS). About 85% of afflicted present with a relapsing-remitting form of the disease (RRMS), for which a breakthrough in treatment was made in 2008 with rituximab, an antibody directed towards CD20, a surface antigen on B-cells. READ MORE

6. 4. Oligodendroglial (dys)function in alpha-synucleinopathies

   Author : Carla Azevedo; Stamcellslaboratoriet för sjukdomsmodellering i det centrala nervsystemet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Synucleinopathies; iPSCs; oligodendrocytes; alpha-synuclein; HLA; cell maturation; immunoproteasome;

   Abstract : The complexity of a-synucleinopathies, which include multiple system atrophy (MSA) and Parkinson’s disease (PD), is not entirely understood. It is known that pathological accumulation of a-synuclein (a-syn) into proteinaceous aggregates is a cellular hallmark of these diseases. READ MORE

7. 5. Stem cell-based models to study cellular alterations in Parkinson’s Disease

   Author : Margarita Chumarina; Stamcellslaboratoriet för sjukdomsmodellering i det centrala nervsystemet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson s disease; stem cells; IPSCs; dopaminergic neurons; oligodendrocytes; omics;

   Abstract : Parkinson’s Disease (PD) is the most prevalent neurodegenerative movement disorder. Despite investigative efforts into the pathogenesis of the disease, the aetiology and mechanism of PD remains unknown, with multiple factors and cellular pathways known to play a part. READ MORE