Search for dissertations about: "Ceramide"

Showing result 6 - 10 of 36 swedish dissertations containing the word Ceramide.

  2. 6. Palmitate-induced Apoptosis in Insulin-producing β-cells

    Author : Kristofer Thörn; Peter Bergsten; Claes Wollheim; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ER stress; apoptosis; palmitate; sphingosine-1-phosphate; ceramide; beta-cell; fatty acid; Medical cell biology; Medicinsk cellbiologi; Medical Cell Biology; Medicinsk cellbiologi;

    Abstract : Type 2 diabetes is a disease characterized by the inability of pancreatic β-cells to secrete sufficient amounts of insulin to maintain normoglycemia. Increased levels of saturated fatty acids such as palmitate are believed to contribute to β-cell failure and the development of the disease. READ MORE

  4. 7. Carbohydrate-Based Inhibitors of Pathogen Adhesion to Cell Surface Glycoconjugates

    Author : Henrik C Hansen; Centrum för analys och syntes; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Galabiose analogs; Globotriose analogs; Escherichia coli; verotoxin; PapG adhesion; Streptococcus suis; Dendrimers; Multivalency; Amino-deoxy analogs; Organic chemistry; Inhibitor; Ceramide analogs; Glycoconjugates; Organisk kemi;

    Abstract : The fact that a growing number of pathogens develop resistance against traditional treatment is a growing medical problem. Infections, which until now have been harmless, might turn into life threatening diseases. These problems have led to an intensified search for alternative treatments. Analogs of cell surface glycoconjugates are an alternative. READ MORE

  5. 8. Characterisation of human adipose tissue : ceramide metabolism, depot differences and evaluation of dysfunctionality

    Author : Joanna Gertow; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Normal adipose tissue function is necessary for maintaining proper energy balance, as both excess and absence of this tissue lead to metabolic disturbances, such as insulin resistance. Adipose tissue can be dysfunctional in many ways, including disturbances in adipocyte size, lipolysis rate, adipokine secretion, inflammation, fibrosis or oxidative stress. READ MORE

  6. 9. Studies of bioactive lipids in cancer

    Author : Vicky Chatzakos; Petra De Verdier; Jenny Flygare; Åke Nilsson; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Lipids; Sphingolipids; N-acyl amino acids; cancer; molekylärgenetik; Molecular Genetics;

    Abstract : Lipids are a broad class of molecules that, besides being a major form of energy storage and components of cell membranes, act as bioactive signalling molecules. N-acyl taurines are structurally related to endocannabinoids that are known to exert antiproliferative actions in a variety of cancer cells. READ MORE

  7. 10. Studies of cannabinoid receptor 1 in mantle cell lymphoma

    Author : Kristin Gustafsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Mantle cell lymphoma (MCL) is a malignant B-cell lymphoma that affects older individuals and has a male predominance. MCL has one of the worst prognoses among lymphomas and currently there is a search for a curative therapy. READ MORE