Search for dissertations about: "Cerebral ischemia"

Showing result 11 - 15 of 110 swedish dissertations containing the words Cerebral ischemia.

  2. 11. A study of potassium channel activation as a pharmacological principle for vasodilation of cerebral blood vessels

    Author : Torsten Ryman; Avdelningen för klinisk kemi och farmakologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacological sciences; cerebral arteries; Cerebral ischemia; Potassium channel openers; vascular endothelium; EDHF; KRN2391; KATP; Pinacidil; pharmacognosy; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi;

    Abstract : Increasing [K+]o is intimately coupled to progressive ischemia and reduced CBF. In isolated cerebral and mesenteric arteries, it was found that significant differences in the vascular responses to [K+]o exist. Among the species studied, human cerebral arteries were the most sensitive artery to increasing [K+]o. READ MORE

  4. 12. Signal Transduction in Focal Cerebral Ischemia : Experimental Studies on VEGF, MAPK and Src family kinases

    Author : Fredrik Lennmyr; Andreas Terént; Tommy Olsson; Uppsala universitet; []
    Keywords : Medical sciences; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medicin; Medicine;

    Abstract : Cerebral ischemia elicits a wide range of events, including complex activation of various intracellular signaling pathways. This study aims to investigate the expression of vascular endothelial growth factor (VEGF) and the activation pattern of mitogen-activated protein kinases (MAPK) in reponse to focal cerebral ischemia. READ MORE

  5. 13. Brain-derived neurotrophic factor in cerebral ischemia: a quantitative study on surviving and newly formed neurons

    Author : Elin Gustafsson; Lund Klinisk fysiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; brain-derived neurotrophic factor; cerebral ischemia; neuronal survival; neurogenesis; hippocampus; striatum; immunocytochemistry; stereology; neuropsykologi; Neurologi; neurophysiology; neuropsychology; neurofysiologi; Neurology;

    Abstract : This study explores the role of brain-derived neurotrophic factor (BDNF) for neuronal vulnerability and neurogenesis following cerebral ischemia in the rat. Cerebral ischemia results in selective neuronal cell loss in specific brain regions. We here demonstrate the rank order of vulnerability in two regions affected by global forebrain ischemia, i. READ MORE

  6. 14. Stroke, Sex and Vascular Receptor Changes in the Brain

    Author : Hilda Ahnstedt; Lund Medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; endothelin receptors; Cerebral ischemia; sex; estrogen; progesterone; sex differences; human cerebral arteries; endothelin-1; angiotensin II; middle cerebral artery occlusion; extra-cellular signal regulated kinase 1 and 2;

    Abstract : Stroke is a severe cerebrovascular disease in which the neuronal tissue and vasculature of the brain undergo ischemia-evoked alterations. We have demonstrated an increased expression of cerebrovascular contractile receptors in the brain. This is hypothesized to mitigate cerebral blood flow and exacerbate tissue damage after stroke. READ MORE

  7. 15. Electrical Bioimpedance Cerebral Monitoring: Fundamental Steps towards Clinical Application

    Author : Fernando Seoane Martinez; KTH; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biomedical Instrumentation; Ischemia; Hypoxia; Non-invasive Monitoring; Electrical Bioimpedance Spectroscopy; Stroke; Impedance Measurements; Brain Monitoring;

    Abstract : Neurologically related injuries cause a similar number of deaths as cancer, and brain damage is the second commonest cause of death in the world and probably the leading cause of permanent disability. The devastating effects of most cases of brain damage could be avoided if it were detected and medical treatment initiated in time. READ MORE