Search for dissertations about: "ChIP-seq"

Showing result 1 - 5 of 28 swedish dissertations containing the word ChIP-seq.

  1. 1. Genome-Wide Studies of Transcriptional Regulation in Mammalian Cells

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Ola Wallerman; Uppsala universitet.; [2010]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ChIP; ChIP-chip; ChIP-seq; transcription factors; motif discovery; nucleosome positioning; HepG2; genome-wide; RNA-seq; MEDICINE Dermatology and venerology; clinical genetics; internal medicine Clinical genetics Medical genetics; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin Klinisk genetik Medicinsk genetik; Medical Genetics; Medicinsk genetik;

    Abstract : The key to the complexity of higher organisms lies not in the number of protein coding genes they carry, but rather in the intrinsic complexity of the gene regulatory networks. The major effectors of transcriptional regulation are proteins called transcription factors, and in this thesis four papers describing genome-wide studies of seven such factors are presented, together with studies on components of the chromatin and transcriptome. READ MORE

  2. 2. Genome-Wide Studies of Transcriptional Regulation in Human Liver Cells by High-throughput Sequencing

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Madhusudhan Reddy Bysani; Uppsala universitet.; [2013]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ChIP-seq; Transcription factors; Alcoholic steatohepatitis; Genome-wide; GWAS; SNPs;

    Abstract : The human genome contains slightly more than 20 000 genes that are expressed in a tissue specific manner. Transcription factors play a key role in gene regulation. By mapping the transcription factor binding sites genome-wide we can understand their role in different biological processes. READ MORE

  3. 3. Functional Studies of Genes Associated with Muscle Growth in Pigs and Hair Greying in Horses

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Lin Jiang; Uppsala universitet.; [2012]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; QTN; muscle development; IGF2; ZBED6; RNA-seq; ChIP-seq; myoblasts; pancreatic beta cells; Grey horse; melanoma; MITF; Biology with specialization in Molecular Cell Biology; Biologi med inriktning mot molekylär cellbiologi;

    Abstract : Domestic animals have become very different from their wild ancestors during domestication and animal breeding. This provides a good model to unravel the molecular mechanisms underlying phenotypic variation. In my thesis I have studied genes affecting two important traits, leanness in pigs and hair greying-associated melanoma in horses. READ MORE

  4. 4. Transcription regulation and growth phase transition in hyperthermoacidophilic archaea

    University dissertation from Stockholm : Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University

    Author : Kun Wang; Stockholms universitet.; [2018]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Archaea; Sulfolobus; Transcription regulation; Lrp; TetR; BarR; ChIP-seq; RNA-seq; Transcriptome; growth phase transition; molekylär biovetenskap; Molecular Bioscience;

    Abstract : Organisms from the domain Archaea are ubiquitously represented on our planet and encompass diverse fascinating organisms. The genus Sulfolobus belonging to the phylum Crenarchaeota including hyperthermoacidophilic strains that grow optimally at 65-85°C and pH 2-3. READ MORE

  5. 5. Genetic and Genomic Analysis of Transcriptional Regulation in Human Cells

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Mehdi Motallebipour; Uppsala universitet.; [2008]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Transcription; ChIP-chip; ChIP-seq; genome-wide; transcription factors; microsatellite; epigenetic; MEDICINE Dermatology and venerology; clinical genetics; internal medicine Clinical genetics Medical genetics; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin Klinisk genetik Medicinsk genetik;

    Abstract : There are around 20.000 genes in the human genome all of which could potentially be expressed. However, it is obvious that not all of them can be active at the same time. Thus, there is a need for coordination achieved through the regulation of transcription. READ MORE