Search for dissertations about: "ChIP-seq"

Showing result 6 - 10 of 40 swedish dissertations containing the word ChIP-seq.

  2. 6. DNA Sequence Variants in Human Autoimmune Diseases

    Author : Chuan Wang; Ann-Christine Syvänen; Anna Lobell; Jeffrey C. Barrett; Uppsala universitet; []
    Keywords : Association study; Gene resequencing; ChIP-seq; Type I interferon system; Systemic lupus erythematosus; Rheumatoid arthritis; Asthma; Medicinsk genetik; Medical Genetics; Molekylär genetik; Molecular Genetics;

    Abstract : Human autoimmune diseases are hallmarked by inappropriate loss-of-tolerance and self-attacking response of the immune system. Studies included in this thesis are focusing on the implication and functional impact of genetic factors in three autoimmune diseases rheumatoid arthritis (RA), asthma, and systemic lupus erythematosus (SLE). READ MORE

  4. 7. Genome-wide epigenetic profiling of B cell leukemia and lymphoma

    Author : Mohammad Hamdy Abdelrazak Morsy; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CLL; PRC2; EZH2; Epigenetics; CpG islands; DNA methylation; ChIP-seq; RNA-seq;

    Abstract : Epigenetic modifications, at the level of DNA methylation and post-translational modifications of histone tails cooperatively function in the organization of the genome, and thereby establish the gene expression profiles, phenotypes, and cellular fates. In this work, we investigated the aberrant epigenome in chronic lymphocytic leukemia (CLL) which is one of the most frequent lymphoid malignancies in the west including the Nordic countries. READ MORE

  5. 8. A Bioinformatics Study of Human Transcriptional Regulation

    Author : Adam Ameur; Jan Komorowski; Claes Wadelius; Philipp Bucher; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; bioinformatics; microarray; ChIP-chip; ChIP-seq; transcription factor; histone modification; motif search; Bioinformatics; Bioinformatik;

    Abstract : Regulation of transcription is a central mechanism in all living cells that now can be investigated with high-throughput technologies. Data produced from such experiments give new insights to how transcription factors (TFs) coordinate the gene transcription and thereby regulate the amounts of proteins produced. READ MORE

  6. 9. Bioinformatic approaches to gene expression in leukemia. Networks and deconvolution

    Author : Linnea Järvstråt; Hematogenomics; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; bioinformatics; acute myeloid leukemia; networks; deconvolution; microarrays; ChIP-seq; DEK; WT1;

    Abstract : The aim of this thesis is develop methods to extract information from high-dimensionality data and to apply them in looking at gene-gene and gene-protein interactions in Acute Myeloid Leukemia (AML). The in silico methods developed can be used with data from other systems. READ MORE

  7. 10. Molecular mechanisms of Yersinia pseudotuberculosis for adaptation and establishment of infection in host tissue

    Author : A. K. M. Firoj Mahmud; Maria Fällman; Matthew S. Francis; Javier Pizarro-Cerda; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; RpoN; T3SS; RNA-Seq; Biofilm; Transcription; Yersinia; Data analysis; ChIP-Seq; biology; biologi;

    Abstract : Bacterial pathogens can evade the host’s immune defence to adapt and establish an infection within the host. Some even slip into a quiescent state to establish themselves without acutely harming the host. Phylogenetically unrelated bacteria can share similar strategies for the establishment of infection and for persistence. READ MORE