Search for dissertations about: "ChemGPS-NP analysis"
Found 4 swedish dissertations containing the words ChemGPS-NP analysis.
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1. Studies on anti-leukemic terpenoids from medicinal mushrooms and marine sponges with ChemGPS-NP-based targets investigation of lead compounds
Abstract : This thesis investigates the anti-leukemic activity of terpenoids isolated from medicinal mushrooms and marine sponges, as well as their possible targets and mechanisms of action.In the first section, we focused on studying the triterpenoidal components of three triterpenoid-enriched medicinal mushrooms Antrodia cinnamomea, Ganoderma lucidum, and Poria cocos, which have been used in folk medicine for centuries and also developed into several contemporary marketed products. READ MORE
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2. ChemGPS-NP and the Exploration of Biologically Relevant Chemical Space
Abstract : Chemical space is basically infinite, and comprises all molecules that could possibly exist. Intelligent ways to efficiently navigate through chemical space and to select promising compounds in drug discovery are important tasks, and the focus of this thesis. In this work a new model for chemical space navigation, ChemGPS-NP, was developed. READ MORE
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3. Exploring evolutionary and chemical space using chemoinformatic tools and traditional methods in pharmacognosy
Abstract : The number of new drugs coming to the market is declining while interest in lead discovery from natural resources is seeing a revival. Although methods for isolation and identification of natural products have advanced tremendously, methods for selection of potential leads have fallen behind. READ MORE
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4. Studies of Cytotoxic Compounds of Natural Origin and their Mechanisms of Action
Abstract : Cancer incidence is increasing and novel anticancer drugs with new mechanisms of action are essential for future chemotherapeutic treatment. Natural products have historically played an important role in the development of anti-cancer drugs and have potential to do so also in the future. READ MORE