Search for dissertations about: "Chemoattractants"

Showing result 11 - 15 of 29 swedish dissertations containing the word Chemoattractants.

  2. 11. Towards a Refined Model of Neutrophil Motility

    Author : Vesa-Matti Loitto; Karl-Eric Magnusson; Tommy Andersson; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; human polymorphonuclear leukocytes. PMNL; neutrophils; neutrophil motility; N-formyl-Met-Leu-Phe; Medical microbiology; Medicinsk mikrobiologi;

    Abstract : The ability of human polymorphonuclear leukocytes (PMNL; neutrophils), to sense and move to sites of infection is essential for our defense against pathogens. Cell motility is critically dependent on a dynamic remodeling of morphology. READ MORE

  4. 12. Recognition by leukocyte formyl peptide receptors. Promiscuous binding or pattern recognition?

    Author : Johan Bylund; Göteborgs universitet; []
    Keywords : neutrophils; chemoattractant; FPRL1; NADPH-oxidase; LPS; priming; subcellular organelles; human; murine;

    Abstract : Neutrophil granulocytes play an important role in the early stages of microbial infection. The neutrophils have to leave the blood stream and migrate out into the tissue where they phagocytose microbes and cell debris from damaged host tissues. READ MORE

  5. 13. New Roles of Filamins in Cell Signaling, Transcription and Organ Development

    Author : Xianghua Zhou; Göteborgs universitet; []
    Keywords : filamins; cell movement; hypoxia-inducible factor 1; proto-oncogene proteins c-met; mice; knockout; F-actin-binding proteins; integrins; GTB phosphohydrolases; genetic diseases; inborn; vascular endothelial cell growth factor A; Smad2 protein; hepatocyte growth factor; cartilage; osteogenesis; neovascularization; neoplasm metastasis;

    Abstract : Filamins are large actin-binding proteins that stabilize delicate three-dimensional actin networks and link them to cellular membranes. They integrate cell architectural and signaling functions and are essential for cell locomotion and development. READ MORE

  6. 14. Vascular targeting for enhanced cancer immunotherapy

    Author : Maria Georganaki; Anna Dimberg; Sara Mangsbo; Lena Claesson-Welsh; Wolf Hervé Fridman; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer immunotherapy; tumor vasculature; endothelial activation; IDO1; ELTD1; tertiary lymphoid organ; Biologi; Biology;

    Abstract : Induced angiogenesis and chronic inflammation are major components of tumor immunosuppression. The scope of this thesis is to understand the role of the vasculature in anti-tumor immunity and thereby to improve cancer immunotherapy. READ MORE

  7. 15. Novel complement regulatory mechanisms in disease

    Author : Emelie Holmquist; Malmö Proteinkemi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : The complement system is one of the most important defence mechanisms against bacteria and pathogens. It acts within the framework of both innate and adaptive immunity. READ MORE