Search for dissertations about: "Chemoattractants"

Showing result 21 - 25 of 29 swedish dissertations containing the word Chemoattractants.

  2. 21. Chemoattractant receptors in drug discovery : FPR2 and CCR2-two potential targets

    Author : Christina Kalderén; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Chemoattractants and chemoattractant receptors have many important functions in multicellular organisms, not least for their role in regulating migration of leukocytes. The receptors are also involved in many pathologies and they have, since they were cloned in the 1990ies, been regarded as attractive targets for development of drugs against cancer, viral infections, and inflammatory/autoimmune diseases. READ MORE

  4. 22. Modulation of PDGF Receptor Signaling via the Phosphatase SHP-2 and the Docking Protein Gab1

    Author : Anders Kallin; Lars Rönnstrand; Carl-Henrik Heldin; Per Lindahl; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; PDGF; SHP-2; Gab1; chemotaxis; actin reorganization; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi;

    Abstract : x.... READ MORE

  5. 23. Leukocyte recruitment and control of vascular permeability in acute inflammation

    Author : Ellinor Kenne; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The inflammatory process is fundamental in host defense against tissue injury or infection. However, the inflammatory reaction may itself cause harm to the host and contribute to tissue damage and organ dysfunction. Leukocyte recruitment and edema formation are key components of the inflammatory response. READ MORE

  6. 24. Ozone and diesel exhaust : airway signaling, inflammation and pollutant interactions

    Author : Jenny Bosson; Anders Blomberg; Thomas Sandström; Ellinor Ädelroth; John Balmes; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; air pollution; ozone; diesel exhaust; airway inflammation; asthma; immunohistochemistry; Lung diseases; Lungsjukdomar; lungmedicin; Lung Medicine;

    Abstract : It is well established that air pollution has detrimental effects on both human health as well as the environment. Exposure to ozone and particulate matter pollution, is associated with an increase in cardiopulmonary mortality and morbidity. Asthmatics, elderly and children have been indicated as especially sensitive groups. READ MORE

  7. 25. Studies of cell migration and matrix protease production in human lung cancer cell lines

    Author : Cecilia G Bredin; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Lung cancer; extracellular matrix; growth factors; matrix metalloproteases; integrins; migration; invasion;

    Abstract : Metastatic spread in cancer is a complex multistep process involving continuous, sequential interactions between tumour cells and their respective microenvironment. Invasiveness per se has not been studied in this thesis, only some of its major components, such as cell migration and matrix protease production. READ MORE