Search for dissertations about: "Chemotherapy in acute lymphoblastic leukemia"

Showing result 1 - 5 of 17 swedish dissertations containing the words Chemotherapy in acute lymphoblastic leukemia.

2. 1. Prognostic factors, treatment and outcome in adult acute lymphoblastic leukemia : Population-based studies in Sweden

   Author : Piotr Kozlowski; Helene Hallböök; Maria Åström; Anita W. Rijneveld; Örebro universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Acute Lymphoblastic Leukemia; adult; chemotherapy; prognosis; population-based; Onkologi; Oncology;

   Abstract : Acute lymphoblastic leukemia (ALL) has poor prognosis in older/elderly adults and in high-risk/relapsed disease. Recommended treatment of ALL was evaluated (study I-IV). Data was obtained from the Swedish Acute Leukemia registries and from patient records.I. READ MORE

4. 2. Optimizing Chemotherapy in Childhood Acute Myeloid Leukemia

   Author : Josefine Palle; Gudmar Lönnerholm; Britt-Marie Frost; Rolf Larsson; Henrik Schröder; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; childhood; acute myeloid leukemia; drug resistance; pharmacokinetics; chromosomal abnormalities; Down syndrome; MLL-rearrangement; t 9; 11 ; Paediatric medicine; Pediatrisk medicin;

   Abstract : Despite major advances in our understanding of the biology of childhood acute myeloid leukemia (AML) and the development of new cytotoxic drugs, the prognosis of long-term survival is still only 60-65 %.In the present research, we studied the pharmacokinetics of drugs used in the induction therapy of childhood AML and performed in vitro drug sensitivity testing of leukemic cells from children with AML. READ MORE

5. 3. Registry-Based Studies in Adult Acute Lymphoblastic Leukemia in Sweden : Survival and Quality of Life

   Author : Emma Bergfelt Lennmyr; Helene Hallböök; Martin Höglund; Jan Maxwell Nørgaard; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Acute Lymphoblastic Leukemia; Philadelphia Chromosome; Overall Survival; Population-based; Quality Registry; Relapse; Patient-Reported Outcome; Health-Related Quality of Life; Depression;

   Abstract : Acute lymphoblastic leukemia (ALL), a common child malignancy, also constitutes a minor fraction of adult cancer with approximately 50 new cases per year in Sweden. While the five-year overall survival (OS) in pediatric ALL is more than 90%, the prognosis in adults is dismal. READ MORE

6. 4. Genetic studies of acute lymphoblastic leukemia

   Author : Ekaterina Kuchinskaya; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Acute lymphoblastic leukemia (ALL) is the most common pediatric malignancy, comprising approximately 25% of all childhood cancers. A huge improvement in outcome of children with ALL during the last 20 years has resulted in remission rates exceeding 95% and a 5 year event-free-survival approaching 80%. READ MORE

7. 5. Identification and Characterization of Stem Cells in Preleukemia and Leukemia

   Author : Lars Nilsson; Stamcellscentrum (SCC); []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Haematology; extracellulära vätskor; Hematologi; Philadelphia chromosome; acute lymphoblastic leukemia; polycytemia vera; 5q- syndrome; myelodysplastic syndromes; self-renewal; preleukemia; Hematopoietic stem cells; leukemic stem cells; extracellular fluids;

   Abstract : Hematopoietic stem cells (HSCs) are responsible for the daily and life long production of large numbers of mature blood cells through highly regulated self-renewal and multilineage capabilities. Leukemias on the other hand, are characterized by a clonal, dysregulated, lineage skewed proliferation and impaired differentiation as the result of multiple accumulated genetic events. READ MORE