Search for dissertations about: "Chinese Hamster Ovary Cell"
Showing result 1 - 5 of 27 swedish dissertations containing the words Chinese Hamster Ovary Cell.
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1. Macroscopic models of Chinese hamster ovary cell cultures
Abstract : Biopharmaceuticals treat a range of diseases, and is a growing sector within the pharmaceutical industry. A majority of these complex molecules are produced by genetically modified mammalian cells in large-scale cell cultures. READ MORE
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2. Molecular Imaging of Diabetic Kidney Tissue and Binding Studies of Proinsulin C-peptide
Abstract : Diabetic kidney disease is a serious complication of diabetes with a complex and incompletely understood pathology. In this work, the molecular changes in diabetic rat kidneys at a very early disease stage were studied using nanospray desorption electrospray ionisation mass spectrometry imaging. READ MORE
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3. High cell density perfusion process development for antibody producing Chinese Hamster Ovary cells
Abstract : Perfusion operation mode is currently under fast expansion in mammalian cell based manufacturing of biopharmaceuticals, not only for labile drug protein but also for stable proteins such as monoclonal antibodies (mAbs). Perfusion mode can advantageously offer a stable cell environment, long-term production with high productivity and consistent product quality. READ MORE
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4. Tools for the development of intensified perfusion processes for mammalian cell culture
Abstract : Recombinant protein therapeutics have become an indispensable part of modern medicine to treat a wide variety of diseases. Their manufacture is mostly based on mammalian cells with fed-batch production bioreactors and downstream batch purification unit operations. READ MORE
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5. The Polyamine Dependence of Cell Cycle Progression-Application in Breast Cancer Treatment
Abstract : In the normal functioning organism, there is a balance between cell proliferation, cell differentiation, and cell death. An imbalance in these processes results in different diseases. This thesis concerns the imbalance where there is too little cell death and cell differentiation with increased cell proliferation. READ MORE