Search for dissertations about: "Chiral LC"

Showing result 1 - 5 of 18 swedish dissertations containing the words Chiral LC.

  2. 1. Development and Validation of Methods for Characterization of Multi-Component Systems in Preparative LC

    Author : Robert Arnell; Torgny Fornstedt; Andreas Seidel-Morgenstern; Uppsala universitet; []
    Keywords : Analytical chemistry; Liquid chromatography; Preparative LC; Chiral LC; Multi-component LC; Adsorption isotherm; Tracer-pulse method; Inverse method; Inverse method on plateaus; Peak deformations; Chiral drug-protein interactions; Analytisk kemi;

    Abstract : This thesis concerns the development and validation of methods for characterization of multi-component preparative LC systems. Measurements of competitive adsorption isotherms are performed to gain detailed information about the interactions inside the chromatography column. READ MORE

  4. 2. Aspects of Porous Graphitic Carbon as Packing Material in Capillary Liquid Chromatography

    Author : Anna Törnkvist; Wolfgang Lindner; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Analytical chemistry; PGC; porous graphitic carbon; stationary phase; packing material; LC; liquid chromatography; miniaturized; chiral; enantiomer; ESI; electrospray ionization; mass spectrometry; polar compounds; L-DOPA; dopamine; biological samples; biological matrix; Analytisk kemi; PGC; poröst grafitiserat kol; stationärfas; packningsmaterial; LC; vätskekromatografi; miniatyriserade system; kiral; enantiomer; ESI; electrospray jonisation; mass spektrometri; polära föreningar; L-DOPA; dopmamine; biologiska prover; biologisk matris; Analytical chemistry; Analytisk kemi; Analytical Chemistry; Analytisk kemi;

    Abstract : In this thesis, porous graphitic carbon (PGC) has been used as packing material in packed capillary liquid chromatography. The unique chromatographic properties of PGC has been studied in some detail and applied to different analytical challenges using both electrospray ionization-mass spectrometry (ESI-MS) and ultra violet (UV) absorbance detection. READ MORE

  5. 3. Heterogeneous Adsorption in Chiral LC

    Author : Gustaf Götmar; Attila Felinger; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi; analytisk farmaceutisk kemi; Analytical Pharmaceutical Chemistry;

    Abstract : The adsorption of chiral drugs on proteins immobilized on silica shows an heterogeneous adsorption behavior on multiple sites. The theory of nonlinear chromatography was used for a systematic study on this behavior - linear chromatography can only measure the "global" retention. READ MORE

  6. 4. Development of LC-MS/MS Methods for the Analysis of Chiral and Achiral Pharmaceuticals and Metabolites in Aqueous Environmental Matrices

    Author : Victoria K.H. Barclay; Curt Pettersson; Monika Johansson; Niklas Tyrefors; Mohamed Abdel-Rehim; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Environmental water matrices; chiral separation; LC-MS MS; trace analysis; method development; active pharmaceutical ingredients; metabolites; Analytical Pharmaceutical Chemistry; Analytisk farmaceutisk kemi;

    Abstract : This thesis describes the development of liquid chromatography tandem mass spectrometry (LC-MS/MS) methods for the trace analysis of active pharmaceutical ingredients (APIs) and their metabolites in aqueous environmental matrices. The research was focused on the development of chiral LC-MS/MS methods for the analysis of fluoxetine and metoprolol, as well as their chiral metabolites in environmental water samples. READ MORE

  7. 5. Determination of the Environmental Fate of Drug Substances and the Matrix Effects of Complex Samples in SFC/ESI-MS

    Author : Alfred Haglind; Curt Pettersson; Mikael Hedeland; Torbjörn Arvidsson; Deirdre Cabooter; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; SFC-MS; matrix effect; ion cluster; Supercritical fluid chromatography; ESI; chiral separation; transformation products; LC-QToF; wetland microcosms; Analytical Pharmaceutical Chemistry; Analytisk farmaceutisk kemi;

    Abstract : Awareness of the potential problems caused by drug compounds in the environment has increased over the last decade, both among researchers and with the public. This thesis describes the development of analytical methods and their application to wetlands constructed for purification of wastewater from e.g. drug compounds. READ MORE