Search for dissertations about: "Chiral analysis"

Showing result 1 - 5 of 62 swedish dissertations containing the words Chiral analysis.

  2. 1. Drug Analysis : Bioanalytical Method Development and Validation

    Author : Mikaela Malm; Yngve Bergqvist; Anders Colmsjö; Uppsala universitet; []
    Keywords : Analytical chemistry; African trypanosomiasis; calibration model; chiral chromatography; dried blood spots; eflornithine; evaporative light-scattering detection; HIV AIDS; lamivudine; liquid chromatography; malaria; nevirapine; piperaquine; pneumonia; solid-phase extraction; sulfadoxine; sulfamethoxazole; validation; zidovudine; Analytisk kemi;

    Abstract : This thesis describes bioanalytical methods for drug determination in biological matrixes, with drugs in focus used against diseases largely affecting low-income countries. Solid-phase extraction is used for sample cleanup, and processed samples are analyzed by liquid chromatography. READ MORE

  4. 2. Sources of dioxins and other POPs to the marine environment : Identification and apportionment using pattern analysis and receptor modeling

    Author : Kristina Sundqvist; Karin Wiberg; Mats Tysklind; Paul Geladi; Miriam Diamond; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; air-water gas exchange; chiral; congener pattern; enantiomer; enantiomeric fraction; fugacity; HCH; hexachlorocyclohexane; homologue profile; indicator congener; isomer pattern; pattern analysis; PCA; PCB; PCDD F; PMF; polychlorinated dibenzofuran; polychlorinated dibenzo-p-dioxin; polychlorinated biphenyl; positive matrix factorization; principal component analysis; receptor modeling; source apportioning; source; source tracing; Environmental chemistry; Miljökemi; Persistent organic compounds; Persistenta organiska föreningar;

    Abstract : In the studies underlying this thesis, various source tracing techniques were applied to environmental samples from the Baltic region. Comprehensive sampling and analysis of polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) in surface sediments in Swedish coastal and offshore areas resulted in a unique data set for this region. READ MORE

  5. 3. Toxicologically important DDT metabolites : Synthesis, enantioselective analysis and kinetics

    Author : Tatiana Cantillana; Åke Bergman; Peter Sundin; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; o; p -DDD; 3-Methylsulfonyl-DDE; adrenocorticolytic compounds; chiral; Environmental chemistry; Miljökemi; Environmental Chemistry; miljökemi;

    Abstract : DDT was extensively and globally used as a pesticide in agriculture and for malaria vector control from the 1940’s until the 1970’s. Due to its heavy use, DDT became ubiquitously distributed throughout the environment. DDT and several DDT metabolites are persistent organic pollutants. READ MORE

  6. 4. Development of LC-MS/MS Methods for the Analysis of Chiral and Achiral Pharmaceuticals and Metabolites in Aqueous Environmental Matrices

    Author : Victoria K.H. Barclay; Curt Pettersson; Monika Johansson; Niklas Tyrefors; Mohamed Abdel-Rehim; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Environmental water matrices; chiral separation; LC-MS MS; trace analysis; method development; active pharmaceutical ingredients; metabolites; Analytical Pharmaceutical Chemistry; Analytisk farmaceutisk kemi;

    Abstract : This thesis describes the development of liquid chromatography tandem mass spectrometry (LC-MS/MS) methods for the trace analysis of active pharmaceutical ingredients (APIs) and their metabolites in aqueous environmental matrices. The research was focused on the development of chiral LC-MS/MS methods for the analysis of fluoxetine and metoprolol, as well as their chiral metabolites in environmental water samples. READ MORE

  7. 5. Separation of Pharmaceuticals by Capillary Electrophoresis using Partial Filling and Multiple-injections

    Author : Henrik Lodén; Curt Pettersson; Torbjörn Arvidsson; Ahmad Amini; Morgan Stefansson; Uppsala universitet; []
    Keywords : Capillary Coating; Chiral Separation; Enantiomers; Mass-spectrometric Detection; Method Validation; Multiple-injection Capillary Zone Electrophoresis; Non-aqueous Capillary Electrophoresis; Organic Solvents; Pharmaceutical Analysis; Quantitative Analysis;

    Abstract : Different multiple-injection methodologies and the partial filling technique (PFT) have been utilized for separation of pharmaceuticals by capillary elec-trophoresis. In multiple-injection capillary zone electrophoresis (MICZE), the samples and all standards, used for construction of the calibration curve, are analyzed within a single run. READ MORE