Search for dissertations about: "Cholera Toxin"

Showing result 1 - 5 of 62 swedish dissertations containing the words Cholera Toxin.

  2. 1. A mouse model for direct evaluation of cholera vaccines

    Author : Erik Nygren; Göteborgs universitet; []
    Keywords : Vibrio cholerae; cholera vaccine; cholera toxin; LPS; anti-bacterial immunity; IgA; challenge; protection; colonization;

    Abstract : Cholera continues to be an important cause of morbidity and mortality in large parts of the developing world and is a significant negative factor for economic development. Vibrio cholerae bacteria of the O1 or O139 serogroup can cause disease due to their ability to colonize the intestine and produce an enterotoxin, cholera toxin (CT). READ MORE

  4. 2. Evaluation of fucosylated receptors for Cholera toxin in the human small intestine

    Author : Jakob Cervin; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cholera toxin; Lewis antigen; HBGA; HMO; Fucose; GM1;

    Abstract : Cholera toxin (CT) produced by Vibrio cholerae is the causative agent for the diarrheal disease cholera. Cholera is yearly afflicting millions and is estimated to kill over 100 000 people every year. In this thesis I aimed to better understand the role of noncanonical CT receptors, e.g. READ MORE

  5. 3. Studies on the immuno-modulating properties of the cholera toxin A1-based fusion protein CTA1-DD

    Author : Anna Eriksson; Göteborgs universitet; []
    Keywords : adjuvant; cholera toxin; mucosa; targeting; B cell; immuno-modulation; vaccine;

    Abstract : The present work was aimed at exploring the immuno-modulating properties of the novel cholera toxin (CT)-based vaccine adjuvant CTA1-DD, which combines the full enzymatic activity of the A1 subunit of CT with B cell targeting. We have studied the efficacy of the CTA1-DD adjuvant to enhance immune responses in mice after nasal administration. READ MORE

  6. 4. Mechanistic studies of the adjuvant effects of CTA1-DD and the native cholera toxin: Impact of cell targeting and tissue localization

    Author : Johan Mattsson; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Vaccines; adjuvants; cholera toxin; germinal center; CTA1-DD; follicular dendritic cells; denritic cells; Th1; Th2; Th17; complement;

    Abstract : Vaccines are the most effective means of preventing infectious diseases and improving global health. However, few vaccines have successfully been developed for protection at mucosal surfaces where most pathogens gain access. READ MORE

  7. 5. Microarray analyses of the small intestinal mucosa during experimental and clinical cholera

    Author : Carl-Fredrik Flach; Göteborgs universitet; []
    Keywords : Vibrio cholerae; cholera toxin; microarray; transporter; intraepithelial lymphocytes; innate defence;

    Abstract : Vibrio cholerae is a Gram-negative bacterium and the causative agent of cholera. The bacteria infect humans via contaminated water and food, and colonize the upper parts of the small intestine to cause disease. The disease is characterized by watery diarrhoea and most of its clinical features can be attributed to the secreted cholera toxin (CT). READ MORE