Search for dissertations about: "Cholesterol homeostasis"

Showing result 1 - 5 of 69 swedish dissertations containing the words Cholesterol homeostasis.

  1. 1. Cholesterol in T cells : homeostasis, plasma membrane organization and signaling

    Author : Saleemulla Mahammad; Ingela Parmryd; Thomas Harder; Stockholms universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Plasma membrane; T cells; Cholesterol; Lipid rafts; Membrane organization; Cholesterol homeostasis; cholesteryl esters; Cell biology; Cellbiologi; cellbiologi; Cellbiology;

    Abstract : The plasma membrane of eukaryotic cells contains cholesterol and glycosphingolipids enriched nanodomains known as lipid rafts; which are believed to exist in a liquid ordered (lo) state. Methyl-beta-cyclodextrin (MBCD) is used to deplete cellular cholesterol and a widespread assumption is that MBCD preferentially targets cholesterol in lipid rafts. READ MORE

  2. 2. Steroid-Metabolizing Cytochrome P450 (CYP) Enzymes in the Maintenance of Cholesterol and Sex Hormone Levels

    Author : Hanna Pettersson; Maria Norlin; Kjell Wikvall; Paolo Parini; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CYP27A1; CYP7B1; cytochrome P450; estrogen receptor; androgen receptor; cholesterol; sex hormone; hydroxylation; steroid metabolism; regulation of steroid levels; Pharmaceutical biochemistry; Farmaceutisk biokemi; Farmaceutisk biokemi; Pharmaceutical Biochemistry;

    Abstract : The enzymes CYP27A1 and CYP7B1 are widely expressed in various human tissues and perform catalytic reactions in cholesterol homeostasis and endocrine signaling. We have investigated the metabolism of a synthetic oxysterol. READ MORE

  3. 3. Cholesterol homeostasis in the brain : importance of 24S-hydroxylation

    Author : Dieter Lütjohann; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : Brain cholesterol is characterized by a very low turnover with very little exchange with lipoproteins in the circulation. We have investigated whether side chain-hydroxylated cholesterol species are important for elimination of cholesterol from the brain. About 80% of 24S-hydroxycholesterol (24S-OH-Chol) present in the body is present in the brain. READ MORE

  4. 4. Statin treatment and beta-Amyloid Production in Patients with Alzheimer s Disease

    Author : Kina Höglund; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : Alzheimer s disease; amyloid precursor protein; beta-amyloid; cholesterol; statins; CSF;

    Abstract : Alzheimer s disease (AD) is a progressive neurodegenerative disorder pathologically characterized by neurofibrillary tangles and amyloid plaques. According to the amyloid cascade hypothesis, the increased production of beta-amyloid (Abeta), derived form the amyloid precursor protein (APP), and its aggregation into plaques are key pathological events, driving neurodegeneration in AD. READ MORE

  5. 5. Phosphoinositides control insulin secretion through multiple routes

    Author : Phuoc My Nguyen; Christina Bark; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Phosphoinositides; PI 4 P; PI 4; 5 P2; Ca2 ; optogenetics; VDCC; Sac2; OSBP; OSW-1; cholesterol; membrane contact sites;

    Abstract : Glucose-stimulated insulin secretion from pancreatic beta cells is the sequence of events that starts with glucose uptake and ends with the fusion of insulin granules with the plasma membrane through Ca2+-triggered exocytosis. Phosphoinositides are minor components of all cellular membranes, yet play fundamental roles as regulators of many cellular processes. READ MORE