Search for dissertations about: "Cholesterol homeostasis"

Showing result 11 - 15 of 72 swedish dissertations containing the words Cholesterol homeostasis.

  2. 11. Studies of sterol 12alpha-hydroxylase (CYP8B1) : distribution and role for cholesterol homeostasis and gallstone formation

    Author : Jin Wang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : CYP8B1; CY7P7A1; bile acid; cholesterol homeostasis; gallstone; nuclear receptor; cellular distribution; cholesterol hypersecretion; ABCG5 G8; SREBP2; cholesterol absorption; diabetes mellitus; anti-atherogenesis;

    Abstract : Bile acids are essential physiological molecules which carry out multiple functions such as facilitating the absorption of dietary lipids and regulating the metabolism of cholesterol and bile acids. The formation of bile represents the major route for elimination of excess cholesterol, either by conversion of cholesterol into bile acids or excretion of intact cholesterol in mixed micelles. READ MORE

  4. 12. Brain cholesterol metabolism : a study of mouse and man

    Author : Maura Heverin; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Alzheimer s Disease; 27-hydroxycholesterol; CYP46A1; cholesterol homeostasis.;

    Abstract : The brain is the most cholesterol rich organ in the body and contains about one quarter of the body's total cholesterol. How this cholesterol and its metabolism affects the complex brain under normal and pathological conditions has been the focus of intense research in recent years due to its possible association with the development or progression of neurodegeneration. READ MORE

  5. 13. PPAR delta : its role in cholesterol metabolism

    Author : Josefin Skogsberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Peroxisome proliferator activated receptor delta; polymorphism; association studies; LDL-cholesterol; coronary heart disease; LDL receptor; gene expression;

    Abstract : Peroxisome proliferator activated receptors (PPARs) are ligand-activated transcription factors that regulate several biological processes, many of which are crucial for energy homeostasis. Three different isotypes have been identified; PPARalpha, PPARdelta and PPARgamma that are encoded by different genes and show different expression patterns and functions. READ MORE

  6. 14. The role of GH in the regulation of energy homeostasis, lipid metabolism and cardiovascular function in transgenic mice

    Author : Bob Olsson; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; growth hormone; cardiovascular disease; energy homeostasis; lipid metabolism; transgenic mice;

    Abstract : The aim of this thesis was, using two transgenic models, to investigate some metabolic diseases associated with acromegaly e.g. hypertension and alterations in lipid and lipoprotein metabolism. READ MORE

  7. 15. Functional study of nuclear receptors and bile acids in the modulation of cholesterol homeostasis

    Author : Xiaoli Hu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cholesterol carries multiple biological functions in the body, and imbalanced cholesterol metabolism leads to atherosclerosis and cardiovascular diseases. The present thesis aims to extend the knowledge of cholesterol metabolic regulation mediated by nuclear receptor LXRs and bile acids, two major players in the homeostasis of body cholesterol. READ MORE