Search for dissertations about: "Cholesterol homeostasis"
Showing result 21 - 25 of 72 swedish dissertations containing the words Cholesterol homeostasis.
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21. Studies on cholesterol and bile acid metabolism in relation to plasma lipoproteins
Abstract : The metabolism of cholesterol and bile acids is tightly controlled but only partially characterized. The liver is responsible for most of the clearance and catabolism of plasma cholesterol, and the hepatocyte expression of LDL receptors is central in this process. READ MORE
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22. Oxysterol receptors LXRs and coregulators in cholesterol metabolism and inflammatory transrepression pathways
Abstract : The LXRs are important sensors and regulators of cholesterol homeostasis in several metabolic tissues including liver, intestine and macrophages. They regulate target genes involved in cholesterol-, lipid- and carbohydrat metabolism. Recently, the LXRs have emerged as important regulators of the innate and adaptive immune system and inflammation. READ MORE
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23. Studies on apolipoprotein E and high cholesterol diet as risk factors for neurodegeneration
Abstract : Elevated level of plasma cholesterol is a well-established risk factor for cardiovascular disease, and emerging evidence suggest that it plays a role in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease (AD). The relations between dietary habits and neurodegeneration are complex, as the brain is selectively separated from peripheral circulation by the blood brain barrier (BBB). READ MORE
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24. Studies on oxysterols : origins, properties and roles
Abstract : Oxysterols are derivatives of cholesterol present at low concentrations in a variety of physiological compartments. The major oxysterols in human circulation are formed from pools of cholesterol that may be distinguished by their miscibility with plasma cholesterol. READ MORE
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25. Studies on the oxysterol receptor LXRβ : linking cholesterol metabolism to water transport and cell proliferation
Abstract : Liver X Receptor β (LXRβ) is a nuclear receptor, belonging to the superfamily of ligand-activated transcription factors. With its α isoform (LXRα), LXRβ shares more than 78% homology in its amino acid sequence, a common profile of oxysterol ligands and the heterodimerization partner, Retinoid X Receptor. READ MORE
