Search for dissertations about: "Cholesterol"

Showing result 6 - 10 of 621 swedish dissertations containing the word Cholesterol.

  2. 6. Plasma membrane order; the role of cholesterol and links to actin filaments

    Author : Jelena Dinic; Ingela Parmryd; Gerrit van Meer; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Membrane Organization; Lipid rafts; Actin; Laurdan; di-4-ANEPPDHQ; Cholesterol; T cell signaling; Colocalization; Generalized Polarization; Cell Biology; cellbiologi;

    Abstract : The connection between T cell activation, plasma membrane order and actin filament dynamics was the main focus of this study. Laurdan and di-4-ANEPPDHQ, membrane order sensing probes, were shown to report only on lipid packing rather than being influenced by the presence of membrane-inserted peptides justifying their use in membrane order studies. READ MORE

  4. 7. Cholesterol-lowering properties of oats: Effects of processing and the role of oat components

    Author : Tina Immerstrand; Avdelningen för livsmedel och läkemedel; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; oats; oat β-glucan; cholesterol; mice;

    Abstract : The cholesterol-lowering effect of oats has been studied for almost fifty years. The effect has hitherto essentially been associated with its content of β-glucans, the primary soluble dietary fibre in oats. READ MORE

  5. 8. Steroid-Metabolizing Cytochrome P450 (CYP) Enzymes in the Maintenance of Cholesterol and Sex Hormone Levels

    Author : Hanna Pettersson; Maria Norlin; Kjell Wikvall; Paolo Parini; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CYP27A1; CYP7B1; cytochrome P450; estrogen receptor; androgen receptor; cholesterol; sex hormone; hydroxylation; steroid metabolism; regulation of steroid levels; Pharmaceutical biochemistry; Farmaceutisk biokemi; Farmaceutisk biokemi; Pharmaceutical Biochemistry;

    Abstract : The enzymes CYP27A1 and CYP7B1 are widely expressed in various human tissues and perform catalytic reactions in cholesterol homeostasis and endocrine signaling. We have investigated the metabolism of a synthetic oxysterol. READ MORE

  6. 9. Implications of cholesterol and cholesterol-lowering therapy in Alzheimer's disease

    Author : Daniel Famer; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Alzheimer s disease; dietary cholesterol; rosuvastatin; apolipoprotein E; alpha-secretase; beta-secretase; alpha- beta-secretase ratio; soluble APPalpha; gliosis; microglial load; interleukin-6; caspase-3; body weight gain; lifestyle-preventive strategy; 24 S -hydroxycholesterol; 27-hydroxycholesterol;

    Abstract : BACKGROUND: Alzheimer's disease (AD) is a severe neurodegenerative disease that mainly afflicts elderly persons, with a characteristic progressive decline of cognitive functions and dementia. It is believed that the majority of all AD patients are affected by the sporadic form, thus caused by the combined effects of several risk factors, such as elevated cholesterol levels in midlife and deficiencies in the lipoprotein transporters apolipoprotein E (ApoE). READ MORE

  7. 10. Statin treatment and beta-Amyloid Production in Patients with Alzheimer s Disease

    Author : Kina Höglund; Göteborgs universitet; []
    Keywords : Alzheimer s disease; amyloid precursor protein; beta-amyloid; cholesterol; statins; CSF;

    Abstract : Alzheimer s disease (AD) is a progressive neurodegenerative disorder pathologically characterized by neurofibrillary tangles and amyloid plaques. According to the amyloid cascade hypothesis, the increased production of beta-amyloid (Abeta), derived form the amyloid precursor protein (APP), and its aggregation into plaques are key pathological events, driving neurodegeneration in AD. READ MORE