Search for dissertations about: "Christopher Schofield"

Found 2 swedish dissertations containing the words Christopher Schofield.

  2. 1. Molecular Approaches to Explore Drug-Target Interactions

    Author : Abdullah Al-Amin; Ulf Landegren; Christopher Schofield; Uppsala universitet; []
    Keywords : Drug discovery; target engagement; target engagement-mediated amplification; cellular thermal shift assay; proximity extension assay; in situ PLA; high-content imaging; Molekylär medicin; Molecular Medicine;

    Abstract : Improved means to assess the clinical potential of drug candidates can critically influence development of new therapeutic entities, a central aim in medical life science. Drug discovery and development relies on construction and selection of small organic compounds or biological agents that bind targets of interest. READ MORE

  4. 2. Development of phosphorus-containing metallo-β-lactamase inhibitors : Synthesis and binding studies by solution NMR and molecular docking

    Author : Katarzyna Palica; Máté Erdélyi; Christopher J. Schofield; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MBL inhibitors; antibiotic resistance; metallo-β-lactamases; NMR spectroscopy; Medicinal Chemistry; Läkemedelskemi;

    Abstract : The rapidly growing bacterial resistance development is turning into one of the main challenges of the 21st century. Our antibiotics are becoming ineffective for the treatment of bacterial infections, and without successful action, simple infections, such as pneumonia or Septicemia, will soon carry a highly probable mortal prognosis. READ MORE