Search for dissertations about: "Chromatin remodelling"

Showing result 1 - 5 of 24 swedish dissertations containing the words Chromatin remodelling.

  2. 1. Gene regulation by chromatin remodelling complexes : SWI/SNF complex in mRNA processing and B-WICH complex in ribosomal gene expression

    Author : Antoni Gañez Zapater; Ann-Kristin Östlund-Farrants; Christopher W.J. Smith; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Chromatin remodelling; SWI SNF; Brg1; Brm; alternative splicing; cleavage and polyadenylation; B-WICH; WSTF; ribosomal genes; Cell Biology; cellbiologi;

    Abstract : The aim of this project is to investigate the roles of chromatin remodelling complexes in gene regulation. It is focused on two groups of chromatin complexes: the mammalian BRG1 and BRM SWI/SNF complexes and the ISWI-containing B-WICH complex.Study 1 investigates the role of SWI/SNF complexes in alternative splicing. READ MORE

  4. 2. RNA Polymerase I regulation by chromatin remodelling

    Author : Yuan Guo; Ann-Kristin Östlund Farrants; Marikki Laiho; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; RNA Pol I; ribosome genes; chromatin remodelling; WSTF; CHD4; molekylär biovetenskap; Molecular Bioscience;

    Abstract : Cell proliferation and growth is correlated with effective protein synthesis and ribosome biogenesis. The transcription of the 47S pre-ribosomal RNA by RNA Polymerase I (RNA Pol I) machinery is the rate-limiting step of ribosome biogenesis and can accounts for more than 50% of total cellular transcription. READ MORE

  5. 3. Chromatin remodelling and gene regulation

    Author : Birgitta Gelius; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Chromatin plays an important role in gene regulation, as it forms an obstacle for a number of proteins that need access to the DNA. Several protein complexes that open up the chromatin structure have been identified and some of these are important for gene regulation. READ MORE

  6. 4. Chromatin remodelling of ribosomal genes - be bewitched by B-WICH

    Author : Anna Vintermist; Ann-Kristin Östlund Farrants; Ross D. Hannan; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; chromatin remodelling; ribosomal genes; rDNA; transcription; RNA polymerase I transcription; RNA polymerase III transcription; Cell Biology; cellbiologi;

    Abstract : Transcription of the ribosomal genes accounts for the majority of transcription in the cell due to the constant high demand for ribosomes. The number of proteins synthesized correlates with an effective ribosomal biogenesis, which is regulated by cell growth and proliferation. READ MORE

  7. 5. Regulation of RNA polymerase I and RNA polymerase III transcription by the chromatin remodelling complex B-WICH

    Author : Fatemeh Sadeghifar; Ann-Kristin Östlund Farrants; Magdalena Boguta; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; B-WICH; Chromatin remodelling; ribosomal genes; transcription; Cell Biology; cellbiologi;

    Abstract : Ribosomal biogenesis is an important process which determines the rate of cell growth and is involved in cell response to proliferation, differentiation, cellular nutritional state and stress. The chromatin remodelling complex B-WICH composed of WSTF, SNF2h and NM1 is involved in transcription by the RNA pol I and RNA pol III. READ MORE