Search for dissertations about: "Chromosomal aberrations"

Showing result 16 - 20 of 91 swedish dissertations containing the words Chromosomal aberrations.

  2. 16. Involvement of evolutionarily plastic regions in cancer associated CHR3 aberrations

    Author : Eva Darai-Ramqvist; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : A functional test to identify tumor antagonizing regions on chromosome 3 (chr3), called the Elimination Test, was developed in our group. It is based on microcell mediated transfer of human chr3 into mouse or human tumor cells and analysis of the monochromosomal hybrids after their growth in vivo. READ MORE

  4. 17. The immortalization process of T cells : with focus on the regulation of telomere length and telomerase activity

    Author : Sofie Degerman; Göran Roos; John Sedivy; Umeå universitet; []
    Keywords : immortalization; senescence; T cells; Nijmegen breakage syndrome; telomere; telomerase; hTERT; generic aberrations; methylation; MEDICINE; MEDICIN; Pathology; patologi;

    Abstract : Cellular immortalization is a major hallmark of cancer and is a multi-step process that requires numerous cell-type specific changes, including inactivation of control mechanisms and stabilization of telomere length. The telomeres at the chromosome ends are essential for genomic stability, and limit the growth potential of most cells. READ MORE

  5. 18. Information prior to prenatal diagnosis : Knowledge, informational needs and decision-making

    Author : Ellen Ternby; Matts Olovsson; Ove Axelsson; Charlotta Ingvoldstad; Susanne Georgsson; Verena Sengpiel; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prenatal diagnosis; decision making; chromosome aberrations; genetic counseling; informed consent; Obstetrik och gynekologi; Obstetrics and Gynaecology;

    Abstract : The overall aim of this thesis was to explore different aspects of information relevant to decision-making regarding prenatal diagnosis (PND) for chromosomal anomalies (CA). In Papers I–II, women and partners undergoing combined ultrasound and biochemistry (CUB) tests, invasive tests or declining PND for CAs answered a questionnaire. READ MORE

  6. 19. Studies on in vitro fertilised human preembryos. Morphological and chromosomal aspects

    Author : Thorir Hardarson; Göteborgs universitet; []
    Keywords : IVF; oocyte; embryo; blastocyst; human; FISH; aneuploidy;

    Abstract : The success rate of in vitro fertilisation (IVF) has gradually increased due to basic research in preembryonic biology and the introduction of new methods, both technical and medical. However, further research is needed to establish which preembryos are developmentally most competent in order to be able to maintain the pregnancy rate while only a single preembryo is being transferred. READ MORE

  7. 20. Chromosomal Instability and Genomic Amplification in Bone and Soft Tissue Tumours

    Author : David Gisselsson Nord; Avdelningen för klinisk genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nuclear atypia; kinetochore; anaphase bridge; p53; breakage-fusion-bridge cycle; TP53; HMGIC; MDM2; mitotic instability; genomic instability; FISH; osteosarcoma; liposarcoma; amplification; tumour; chromosome; cytogenetics; Clinical genetics; Klinisk genetik;

    Abstract : Acquired genetic abnormalities are found in all types of malignant tumours and may contribute to neoplastic processes by altering protein structure or dosage. Many bone and soft tissue tumours (BSTT) are characterised by complex patterns of chromosome changes, including extensive intratumour heterogeneity and amplification of DNA sequences. READ MORE