Search for dissertations about: "Chromosome 11"

Showing result 1 - 5 of 97 swedish dissertations containing the words Chromosome 11.

  2. 1. Chromosome aberrations and environmental exposures in acute leukemia

    Author : Ragnhild Rosengren Lindquist; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Acute leukemia; chromosome 3; chromosome 8; fragile site; occupational exposure; mutagen exposure; case-control study; trisomy; benzene; organic solvent; petroleum; epidemiology; environmental carcinogens; painter; driver;

    Abstract : The aims of this thesis are to evaluate the role of environmental exposures, especially professional exposure to organic solvents and petroleum products in the etiology of acute leukemia and to investigate if there is a correlation between the exposure to a specific leukemogen factor and a clonal chromosome aberration of the leukemic cells. Papers I and II present results of a case-control study of environmental exposures, in all occupations during life-time, medical treatments with medicines, chemotherapy and radiation, tobacco-use and the exposure to chemical compounds in private life in 120 patients with acute leukemia and of 120 controls, matched for age (+ 4 years), residence and sex. READ MORE

  4. 2. Proteins influencing the integrity of meiotic chromosome dynamics

    Author : Mary-Rose Hoja; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Aneuploidy (trisomy or monosomy) is the leading genetic cause of human pregnancy loss and results from aberrant meiotic chromosome segregation. Accurate segregation of meiotic chromosomes depends on extensive pairing (called synapsis) and recombination between them. READ MORE

  5. 3. Prenatal diagnosis of structural malformations and chromosome anomalies : Detection, influence of Body Mass Index and ways to improve screening

    Author : Eric Hildebrand; Marie Blomberg; Tomas Gottvall; Jan Brynhildsen; Ove Axelsson; Linköpings universitet; []
    Keywords : ;

    Abstract : Introduction: Prenatal diagnosis of structural malformations and chromosome anomalies is possible in the presence of an effective screening with ultrasound during pregnancy. The continuous evolution of the ultrasound equipment facilitates the examination. READ MORE

  6. 4. Characterization of human chromosome 22 : cloning of breakpoints of the constitutional translocation t(11;22)(q23;q11) and detection of small constitutional delections by microarray CGH

    Author : Isabel Tapia Paez; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Chromosome 22; t 11; 22 q23; q 11 ; inverted repeats palindromes; DiGeorge Velo-cardio-facial syndrome; array-CGH;

    Abstract : Chromosome 22 is the second smallest human chromosome, composing approximately 1.5% of the genome. The short arm of this acrocentric chromosome harbors ribosomal genes and the long arm contains the protein coding genes. READ MORE

  7. 5. Microtubule and chromosome dynamics during mitosis in budding yeast

    Author : Alexander Julner Dunn; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : As a cell divides, DNA must be replicated and faithfully segregated between the mother and daughter cells. This segregation is facilitated by the mitotic spindle, assembled to pull sister chromatids apart as the cell divides. READ MORE