Search for dissertations about: "Chronic lymphoblastic leukemia"
Showing result 1 - 5 of 13 swedish dissertations containing the words Chronic lymphoblastic leukemia.
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1. Stem and progenitor cell involvement in acute lymphoblastic leukemia
Abstract : Leukemic stem cells (LSCs) share the capacity of self renewal and extensive proliferation with normal hematopoietic stem cells (HSCs), and are therefore obvious targets for therapy. As such, they need to be identified and characterized in order to elucidate what drives them, and what separates them from their normal counterparts. READ MORE
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2. Minimal Residual Disease Assessment in Childhood Acute Lymphoblastic Leukemia
Abstract : Traditionally, response to treatment in hematological malignancies is evaluated by light microscopy of bone marrow (BM) smears, but due to more effective therapies more sensitive methods are needed. Today, detection of minimal residual disease (MRD) using immunological and molecular techniques can be 100 times more sensitive than morphology. READ MORE
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3. Molecular and functional studies of the BCR/ABL1 fusion gene
Abstract : The BCR/ABL1 fusion gene is associated with chronic myeloid leukemia and a subgroup of acute lymphoblastic leukemia. The general aim of this thesis was to increase the understanding of BCR/ABL1-induced leukemogenesis by molecular and functional studies of this fusion gene. READ MORE
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4. Prognostic molecular markers of childhood leukemia
Abstract : During the last decades there has been a dramatic increase in survival rates for childhood leukemia, resulting today in an overall survival close to 90 % for children with acute lymphoblastic leukemia (ALL). This accomplishment is largely due to treatment protocols based on careful risk group assessment guiding the type and intensity of the anti-leukemic treatment. READ MORE
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5. Register-based studies on childhood cancer : relapsed childhood acute lymphoblastic leukemia and skeletal adverse events in childhood cancer survivors in the Nordic countries
Abstract : Background: Although cancer is a rare disease in children, it is the leading disease-related cause of death in children and adolescents in developed countries. Currently 80% of patients become long-time survivors but if a relapse occurs the outcome for most patients is still poor. READ MORE