Search for dissertations about: "Chronic lymphoid leukemia"

Showing result 1 - 5 of 31 swedish dissertations containing the words Chronic lymphoid leukemia.

  2. 1. Genetic changes in lymphoid leukemia

    Author : Marianne Hammarsund; Karolinska Institutet; Karolinska Institutet; []
    Keywords : CLL; HCL; genetic aberrations; 13q14; chromosome 5; antisense; bicistronic;

    Abstract : It is today generally accepted that the vast majority of malignant tumors arise as a result of genetic changes in critical genes involved in the tightly regulated control of cell growth and cell death. Despite the remarkable progress in the identification of such genes during the past two decades, many cancer genes probably remain to be identified. READ MORE

  4. 2. Targeted therapy in chronic lymphocytic leukemia

    Author : Maria Winqvist; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of mature B lymphocytes in blood, bone marrow and lymphoid tissues. Historically, patients with TP53 aberration and with refractoriness to chemoimmunotherapy had a dismal prognosis. READ MORE

  5. 3. Prognostic markers in pediatric leukemia and mechanisms of KRAS induced leukemogenesis

    Author : Anna Staffas; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prognostic markers; AML; T-ALL; leukemia; FLT3; NPM1; ERG; BAALC; KRAS;

    Abstract : Leukemia results from uncontrolled growth of genetically altered blood cells. Depending on the cell type of origin, the leukemia is defined as T-cell, B-cell, or myeloid and as acute or chronic depending on its characteristics. However, patients with a certain subtype of leukemia (e.g. READ MORE

  6. 4. Aspects on long-term treatment with tyrosine kinase inhibitors in Chronic myeloid leukemia

    Author : Sofia Jönsson; Göteborgs universitet; []
    Keywords : Chronic myeloid leukemia; tyrosine kinase inhibitor; imatinib; molecular response; adherence; mesechymal stem cells; osteoblast differentiation; dasatinib;

    Abstract : Chronic myeloid leukemia (CML) is caused by the tyrosine kinase activity of the oncoprotein BCR-ABL. The introduction of tyrosine kinase inhibitors (TKIs) targeting BCR-ABL has profoundly changed the prognosis of CML. Currently, there are three TKIs approved for treatment of CML, imatinib, nilotinib and dasatinib. READ MORE

  7. 5. Clinical prognostic markers in chronic lymphocytic leukemia

    Author : Stefan Norin; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of mature B lymphocytes in blood, bone marrow and lymphoid tissues. The clinical course for the individual patient is still unpredictable despite decades of research on prognostic markers and staging systems. READ MORE